iPTMnet Report for Q8TDQ0 (HAVCR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDQ0 / HAVR2_HUMAN
Protein Name Hepatitis A virus cellular receptor 2 precursor
Gene Name Name: HAVCR2
Synonyms:TIM3,TIMD3;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDQ0
DAG View
PRO Name hepatitis A virus cellular receptor 2 (human)
Definition A hepatitis A virus cellular receptor 2 that is encoded in the genome of human.
Short Label hHAVCR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDQ0 (HAVCR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C9 Methylation IEDB 31844290
S105 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
T145 O-Glycosylation GlyGen   UniProt 30459171, 32022078, 22171320
T153 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
T174 O-Glycosylation GlyGen 30459171
T178 O-Glycosylation GlyGen 30459171
S238 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation Q08881 (ITK) PhosphoSitePlus   RLIMS-P   UniProt 17069754, 23967307
Y272 Phosphorylation PhosphoSitePlus
C296 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 I105 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K126 M126 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K126 E126 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T153 I153 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S241 F241 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S241 P241 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]