iPTMnet Report Q8TDQ0 HAVCR2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q8TDQ0 / HAVR2_HUMAN
Protein Name	Hepatitis A virus cellular receptor 2 precursor
Gene Name	Name: HAVCR2 Synonyms:TIM3,TIMD3;
Organism	Homo sapiens (Human)

PRO ID	PR:Q8TDQ0 DAG View
PRO Name	hepatitis A virus cellular receptor 2 (human)
Definition	A hepatitis A virus cellular receptor 2 that is encoded in the genome of human.
Short Label	hHAVCR2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q8TDQ0 (HAVCR2) as Substrate

Q8TDQ0

Expanded View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position C9 S105 Y108 K126 T145 T153 T154 T174 T178 S238 S241 Y265 Y272 C296	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation	PTM Enzyme	Score Select all 1 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P UniProt	PMID
	C9	Methylation		score1	IEDB	31844290
	S105	Phosphorylation		score1	PhosphoSitePlus
	Y108	Phosphorylation		score1	PhosphoSitePlus
	K126	Acetylation		score1	PhosphoSitePlus
	T145	O-Glycosylation		score4	GlyGen UniProt	30459171, 32022078, 22171320
	T153	Phosphorylation		score1	PhosphoSitePlus
	T154	Phosphorylation		score1	PhosphoSitePlus
	T174	O-Glycosylation		score1	GlyGen	30459171
	T178	O-Glycosylation		score1	GlyGen	30459171
	S238	Phosphorylation		score1	PhosphoSitePlus
	S241	Phosphorylation		score1	PhosphoSitePlus
	Y265	Phosphorylation	Q08881 (ITK)	score4	PhosphoSitePlus RLIMS-P UniProt	17069754, 23967307
	Y272	Phosphorylation		score1	PhosphoSitePlus
	C296	Methylation		score1	IEDB	31844290

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S105 K126 T153 S241	Variant Select all E126 F241 I105 I153 M126 P241	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5158 / pleural cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S105	I105	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
K126	M126	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ]
K126	E126	Biomuta		DOID:10534 / stomach cancer [ cosmic ]
T153	I153	Biomuta		DOID:5158 / pleural cancer [ cosmic ]
S241	F241	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S241	P241	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]