iPTMnet Report for Q8TDN6 (BRIX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDN6 / BRX1_HUMAN
Protein Name Ribosome biogenesis protein BRX1 homolog
Gene Name Name: BRIX1
Synonyms:BRIX,BXDC2;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDN6
DAG View
PRO Name ribosome biogenesis protein BRX1 homolog (human)
Definition A brix domain-containing protein 2 that is encoded in the genome of human.
Short Label hBRIX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDN6 (BRIX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R9 Methylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
C52 Methylation IEDB 31844290
K53 Ubiquitination PhosphoSitePlus
R82 Methylation PhosphoSitePlus
C107 Methylation IEDB 31844290
Y127 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
C158 Methylation IEDB 31844290
Y178 Phosphorylation PhosphoSitePlus
T252 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y254 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
Y259 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
K276 Acetylation PhosphoSitePlus   UniProt 19608861
K276 Ubiquitination PhosphoSitePlus
T296 O-Glycosylation GlyGen 33214551, 34229054, 35083852, ...34019948, 35254053
T303 O-Glycosylation GlyGen 33214551, 34229054, 35083852, ...34019948, 35254053
T309 O-Glycosylation GlyGen 33214551, 34229054, 35083852, ...34019948, 35254053
T309 Phosphorylation PhosphoSitePlus
K314 Sumoylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C158 R158 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S261 L261 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K322 T322 Biomuta DOID:9256 / colorectal cancer [ cosmic ]