iPTMnet Report for Q8TDJ6 (DMXL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDJ6 / DMXL2_HUMAN
Protein Name DmX-like protein 2
Gene Name Name: DMXL2
Synonyms:KIAA0856;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDJ6
DAG View
PRO Name DmX-like protein 2 (human)
Definition A DmX-like protein 2 that is encoded in the genome of human.
Short Label hDMXL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDJ6 (DMXL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C192 Methylation IEDB 31844290
Y198 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
C356 Methylation IEDB 31844290
S434 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   UniProt 23186163
S481 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
C658 Methylation IEDB 31844290
S685 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
C832 Methylation IEDB 31844290
S925 Phosphorylation PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S944 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S945 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T948 Phosphorylation phospho.ELM 18669648
S949 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S960 Phosphorylation PhosphoSitePlus
T966 Phosphorylation PhosphoSitePlus
K1049 Acetylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1143 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1151 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1157 Ubiquitination PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
T1300 Phosphorylation PhosphoSitePlus
K1365 Ubiquitination PhosphoSitePlus
T1398 Phosphorylation PhosphoSitePlus
S1400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15144186
S1402 Phosphorylation PhosphoSitePlus
S1404 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
Y1456 Phosphorylation PhosphoSitePlus
Y1468 Phosphorylation PhosphoSitePlus
K1488 Ubiquitination PhosphoSitePlus
S1515 Phosphorylation PhosphoSitePlus
S1516 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
K1710 Ubiquitination PhosphoSitePlus
K1718 Ubiquitination PhosphoSitePlus
K1781 Ubiquitination PhosphoSitePlus
T1809 O-Glycosylation GlyGen 30379171, 28411811
K1821 Ubiquitination PhosphoSitePlus
S1857 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
T1861 Phosphorylation PhosphoSitePlus
K1876 Acetylation PhosphoSitePlus
K1876 Ubiquitination PhosphoSitePlus
K1907 Ubiquitination PhosphoSitePlus
K1913 Ubiquitination PhosphoSitePlus
K1921 Ubiquitination PhosphoSitePlus
Y1960 Phosphorylation PhosphoSitePlus
S1984 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y2062 Phosphorylation PhosphoSitePlus
T2101 Phosphorylation PhosphoSitePlus
Y2102 Phosphorylation PhosphoSitePlus
S2103 Phosphorylation PhosphoSitePlus
S2123 Phosphorylation PhosphoSitePlus
S2197 Phosphorylation PhosphoSitePlus
S2330 Phosphorylation PhosphoSitePlus
S2331 Phosphorylation PhosphoSitePlus
S2399 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2434 Phosphorylation PhosphoSitePlus
K2560 Ubiquitination PhosphoSitePlus
K2591 Ubiquitination PhosphoSitePlus
K2602 Methylation PhosphoSitePlus
S2640 Phosphorylation PhosphoSitePlus
Y2717 Phosphorylation PhosphoSitePlus
Y2777 Phosphorylation PhosphoSitePlus
S2786 Phosphorylation IEDB 35494241
C2800 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S585 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 20068231
S929 Phosphorylation HPRD 20058876
S944 Phosphorylation HPRD 18669648
S945 Phosphorylation HPRD 18669648
T948 Phosphorylation HPRD 18669648
S949 Phosphorylation HPRD 18669648
S1400 Phosphorylation HPRD 18669648, 15144186
S1404 Phosphorylation HPRD 15144186
S1857 Phosphorylation HPRD 18691976, 18669648, 20068231
S1984 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S325 L325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S451 F451 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S929 F929 Biomuta DOID:4159 / skin cancer [ cosmic ]
S944 Y944 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S949 F949 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1157 N1157 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1299 L1299 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T1300 A1300 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1365 E1365 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1402 N1402 Biomuta DOID:1319 / brain cancer [ icgc ]
Y1456 C1456 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1857 F1857 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1913 E1913 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T2101 I2101 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2331 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2777 C2777 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y2777 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2786 N2786 Biomuta DOID:363 / uterine cancer [ icgc ]