iPTMnet Report for Q8TDI7 (TMC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDI7 / TMC2_HUMAN
Protein Name Transmembrane channel-like protein 2
Gene Name Name: TMC2
Synonyms:C20orf145;ORFNames:UNQ907/PRO1928;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDI7
DAG View
PRO Name transmembrane channel-like protein 2 (human)
Definition A transmembrane channel-like protein 2 that is encoded in the genome of human.
Short Label hTMC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDI7 (TMC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
Y496 Phosphorylation PhosphoSitePlus
T597 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S842 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S140 F140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S147 F147 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T489 I489 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y496 F496 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y496 H496 Biomuta DOID:4159 / skin cancer [ cosmic ]