iPTMnet Report for Q8TDG4 (HELQ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDG4 / HELQ_HUMAN
Protein Name Helicase POLQ-like
Gene Name Name: HELQ
Synonyms:HEL308;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDG4
DAG View
PRO Name helicase POLQ-like (human)
Definition An ATP-dependent DNA helicase HEL308 that is encoded in the genome of human.
Short Label hHELQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDG4 (HELQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
N208 N-Glycosylation GlyGen 29671580
S250 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T425 O-Glycosylation GlyGen 29485866, 30379171
T480 Phosphorylation PhosphoSitePlus
K529 Acetylation PhosphoSitePlus
K554 Acetylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
Y701 Phosphorylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
Y818 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
Y942 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N208 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T425 A425 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T480 A480 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K702 E702 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T816 S816 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S820 F820 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]