iPTMnet Report for Q8TDD1 (DDX54)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDD1 / DDX54_HUMAN
Protein Name ATP-dependent RNA helicase DDX54
Gene Name Name: DDX54
Organism Homo sapiens (Human)

PRO ID PR:Q8TDD1
DAG View
PRO Name ATP-dependent RNA helicase DDX54 (human)
Definition An ATP-dependent RNA helicase DDX54 that is encoded in the genome of human.
Short Label hDDX54
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDD1 (DDX54) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
S34 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
S41 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...19690332
S71 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
T74 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S75 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S95 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
K312 Methylation PhosphoSitePlus
C365 Methylation IEDB 31844290
K383 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
S644 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S660 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus   UniProt 20068231
S698 Phosphorylation PhosphoSitePlus   UniProt 20068231
S743 Phosphorylation PhosphoSitePlus
T753 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
S782 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
S788 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
R802 Methylation PhosphoSitePlus
T814 Phosphorylation PhosphoSitePlus
R820 Methylation PhosphoSitePlus
R844 Methylation PhosphoSitePlus
R868 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation HPRD 18669648, 17081983, 20068231
S39 Phosphorylation HPRD 17081983, 19691289, 18452278, ...19651622, 18669648, 20068231
S41 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T67 Phosphorylation HPRD 17081983
S71 Phosphorylation HPRD 18669648
T74 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S75 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 18669648, 20068231
T120 Phosphorylation HPRD 20068231
T182 Phosphorylation HPRD 20068231
S644 Phosphorylation HPRD 18669648
S696 Phosphorylation HPRD 17081983, 20068231
S698 Phosphorylation HPRD 20068231
S782 Phosphorylation HPRD 17322306, 18212344, 19691289, ...19007248, 19651622, 18669648, 19415658, 20068231
S788 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T815 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T142 M142 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K159 N159 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S173 L173 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K383 N383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S527 L527 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S644 R644 Biomuta DOID:4159 / skin cancer [ cosmic ]
S755 R755 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S782 L782 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S788 Y788 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R802 H802 Biomuta DOID:1319 / brain cancer [ cosmic ]
R802 C802 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R820 C820 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ]
R844 L844 Biomuta DOID:4606 / bile duct cancer [ cosmic ]