Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDC3 / BRSK1_HUMAN
Protein Name Serine/threonine-protein kinase BRSK1
Gene Name Name: BRSK1
Synonyms:KIAA1811,SAD1,SADB;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDC3
DAG View
PRO Name serine/threonine-protein kinase BRSK1 (human)
Definition A serine/threonine-protein kinase BRSK1 that is encoded in the genome of human.
Short Label hBRSK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDC3 (BRSK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Sumoylation PhosphoSitePlus
T189 Phosphorylation Q15831 (STK11) , Q8N5S9 (CAMKK1) , Q8TDC3 (BRSK1) neXtProt   PhosphoSitePlus   Signor   UniProt 16630837, 22020259, 14976552, ...18339622, 18324781, 19648910, 19958286
S193 Phosphorylation Q8TDC3 (BRSK1) neXtProt 19648910, 16630837
S275 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
R431 Methylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
R481 Methylation PhosphoSitePlus
R484 Methylation PhosphoSitePlus
R498 Methylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus   UniProt 23186163
R510 Methylation PhosphoSitePlus
T523 Phosphorylation PhosphoSitePlus
R525 Methylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
T772 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K79 Ubiquitination PhosphoSitePlus
T205 Phosphorylation Q8N5S9 (CAMKK1) , Q8TDC3-2 (BRSK1) , Q15831 (STK11) PhosphoSitePlus 19958286, 14976552, 16630837
S209 Phosphorylation Q8TDC3-2 (BRSK1) PhosphoSitePlus 16630837
K288 Acetylation PhosphoSitePlus
R514 Methylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus


Q8TDC3 (BRSK1) as PTM Enzyme



Substrate Site Score Source PMID
P10636 (MAPT) T529 neXtProt 21985311
P10636 (MAPT) S579 neXtProt 15705853
P23258 (TUBG1) S131 neXtProt   PhosphoSitePlus   Signor 19648910, 24942739
P23258 (TUBG1) S385 PhosphoSitePlus 24942739
P30291 (WEE1) S642 HPRD   neXtProt   PhosphoSitePlus 15150265
P30305 (CDC25B) S375 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15150265
P30307 (CDC25C) S216 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9543386, 10557092, 9278512, ...15150265, 11333986, 11551930, 19648910, 20068231
Q13131 (PRKAA1) T183 PhosphoSitePlus 18854318
Q8TDC3 (BRSK1) T189 neXtProt 19648910, 16630837
Q8TDC3 (BRSK1) S193 neXtProt 19648910, 16630837
Q8TDC3-2 (BRSK1) T205 PhosphoSitePlus 16630837
Q8TDC3-2 (BRSK1) S209 PhosphoSitePlus 16630837


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S404 C404 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S404 N404 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R431 C431 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ]
S443 I443 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R481 Q481 Biomuta DOID:0070003 / blastoma [ cosmic ]
R484 S484 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R498 H498 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S559 G559 Biomuta DOID:1324 / lung cancer [ cosmic ]
S559 N559 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S743 I743 Biomuta DOID:3571 / liver cancer [ icgc ]