iPTMnet Report for Q8TD55 (PLEKHO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TD55 / PKHO2_HUMAN
Protein Name Pleckstrin homology domain-containing family O member 2
Gene Name Name: PLEKHO2
Synonyms:PLEKHQ1;ORFNames:PP9099;
Organism Homo sapiens (Human)

PRO ID PR:Q8TD55
DAG View
PRO Name pleckstrin homology domain-containing family O member 2 (human)
Definition A pleckstrin homology domain-containing family O member 2 that is encoded in the genome of human.
Short Label hPLEKHO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TD55 (PLEKHO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
C135 S-Nitrosylation dbSNO 22126794
S164 Phosphorylation PhosphoSitePlus   UniProt 24275569
S167 Phosphorylation PhosphoSitePlus   UniProt 24275569
T224 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus   UniProt 24275569
S278 Phosphorylation PhosphoSitePlus
C295 S-Nitrosylation dbSNO 26338901
T311 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T338 Phosphorylation IEDB 32387766
S349 O-Glycosylation GlyGen 29351928
T364 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R400 Methylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S256 Phosphorylation HPRD 20058876
S389 Phosphorylation HPRD 20058876
S390 Phosphorylation HPRD 20058876, 19664995
S468 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C135 F135 Biomuta DOID:1324 / lung cancer [ cosmic ]
S164 G164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S167 F167 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S167 A167 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S273 N273 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S278 I278 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S420 L420 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]