iPTMnet Report for Q8TD26 (CHD6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TD26 / CHD6_HUMAN
Protein Name Chromodomain-helicase-DNA-binding protein 6
Gene Name Name: CHD6
Synonyms:CHD5,KIAA1335,RIGB;
Organism Homo sapiens (Human)

PRO ID PR:Q8TD26
DAG View
PRO Name chromodomain-helicase-DNA-binding protein 6 (human)
Definition A chromodomain-helicase-DNA-binding protein 6 that is encoded in the genome of human.
Short Label hCHD6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TD26 (CHD6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S161 O-Glycosylation GlyGen 30379171
T163 O-Glycosylation GlyGen 30379171
K183 Acetylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
T334 Phosphorylation PhosphoSitePlus
K340 Acetylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
Y749 Phosphorylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K900 Acetylation PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K929 Ubiquitination PhosphoSitePlus
T941 Phosphorylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
K1040 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus
S1174 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
Y1237 Phosphorylation PhosphoSitePlus
Y1238 Phosphorylation PhosphoSitePlus
K1250 Ubiquitination PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
K1311 Ubiquitination PhosphoSitePlus
T1327 Phosphorylation PhosphoSitePlus
T1339 Phosphorylation PhosphoSitePlus
K1444 Ubiquitination PhosphoSitePlus
Y1459 Phosphorylation PhosphoSitePlus
Y1469 Phosphorylation PhosphoSitePlus
S1491 Phosphorylation PhosphoSitePlus
Y1500 Phosphorylation PhosphoSitePlus
Y1540 Phosphorylation PhosphoSitePlus
K1590 Ubiquitination PhosphoSitePlus
Y1640 Phosphorylation PhosphoSitePlus
Y1645 Phosphorylation PhosphoSitePlus
S1654 Phosphorylation PhosphoSitePlus
S1667 Phosphorylation PhosphoSitePlus
S1673 Phosphorylation PhosphoSitePlus
S1684 Phosphorylation PhosphoSitePlus
K1710 Ubiquitination PhosphoSitePlus
K1711 Ubiquitination PhosphoSitePlus
S1714 Phosphorylation PhosphoSitePlus
S1719 Phosphorylation PhosphoSitePlus
S1723 Phosphorylation PhosphoSitePlus
S1725 Phosphorylation PhosphoSitePlus
T1728 Phosphorylation PhosphoSitePlus
S1785 Phosphorylation PhosphoSitePlus
S1839 Phosphorylation PhosphoSitePlus
S1840 Phosphorylation PhosphoSitePlus
K1851 Ubiquitination PhosphoSitePlus
S1852 Phosphorylation PhosphoSitePlus
S1855 Phosphorylation PhosphoSitePlus
T1897 Phosphorylation PhosphoSitePlus
T1898 Phosphorylation PhosphoSitePlus
T1923 Phosphorylation PhosphoSitePlus
K1959 Ubiquitination PhosphoSitePlus
T1972 Phosphorylation PhosphoSitePlus
K1992 Sumoylation PhosphoSitePlus
K1997 Ubiquitination PhosphoSitePlus
S2041 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K2083 Ubiquitination PhosphoSitePlus
K2172 Ubiquitination PhosphoSitePlus
Y2181 Phosphorylation PhosphoSitePlus
K2356 Ubiquitination PhosphoSitePlus
S2402 Phosphorylation PhosphoSitePlus
K2412 Ubiquitination PhosphoSitePlus
R2417 Methylation PhosphoSitePlus
K2424 Ubiquitination PhosphoSitePlus
S2652 Phosphorylation PhosphoSitePlus
K2654 Ubiquitination PhosphoSitePlus
S2674 Phosphorylation PhosphoSitePlus
S2680 Phosphorylation PhosphoSitePlus
S2710 Phosphorylation PhosphoSitePlus
T2714 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation HPRD 17924679
S1069 Phosphorylation HPRD 17081983
S1073 Phosphorylation HPRD 17081983
S1714 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 P24 Biomuta [ cosmic ]
S36 F36 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S41 L41 Biomuta DOID:4159 / skin cancer [ cosmic ]
T42 P42 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S53 N53 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S78 F78 Biomuta DOID:4159 / skin cancer [ cosmic ]
K134 N134 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K134 M134 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y327 S327 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T334 S334 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T334 A334 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K424 T424 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K436 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T493 A493 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K717 N717 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K743 N743 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1003 N1003 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1073 R1073 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S1073 C1073 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1174 L1174 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y1237 H1237 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y1237 * Biomuta DOID:1612 / breast cancer [ cosmic ]
T1339 S1339 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1444 N1444 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1459 C1459 Biomuta DOID:2394 / ovarian cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1491 L1491 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S1673 N1673 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1719 F1719 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S1719 Y1719 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1728 I1728 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1785 L1785 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1851 N1851 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1959 N1959 Biomuta DOID:10283 / prostate cancer [ icgc ]
T1972 S1972 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K2412 M2412 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T2714 A2714 Biomuta DOID:10283 / prostate cancer [ cosmic ]