iPTMnet Report for Q8TCU6 (PREX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TCU6 / PREX1_HUMAN
Protein Name Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Gene Name Name: PREX1
Synonyms:KIAA1415;
Organism Homo sapiens (Human)

PRO ID PR:Q8TCU6
DAG View
PRO Name phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (human)
Definition A phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein that is encoded in the genome of human.
Short Label hPREX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TCU6 (PREX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C52 Methylation IEDB 31844290
C143 Methylation IEDB 31844290
S174 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
C269 Methylation IEDB 31844290
T308 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   RLIMS-P 27788493
S319 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27788493, 23186163
T333 Phosphorylation PhosphoSitePlus
S436 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 26797121
T437 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus   RLIMS-P 27788493
K624 Ubiquitination PhosphoSitePlus
K642 Acetylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
T704 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
C901 Methylation IEDB 31844290
K926 Ubiquitination PhosphoSitePlus
C936 Methylation IEDB 31844290
K945 Ubiquitination PhosphoSitePlus
T985 O-Glycosylation GlyGen 35132862, 29351928
S987 O-Glycosylation GlyGen 35132862, 29351928
S991 Phosphorylation PhosphoSitePlus
K999 Sumoylation PhosphoSitePlus
S1001 Phosphorylation IEDB   PhosphoSitePlus 29493099
C1032 Methylation IEDB 31844290
S1049 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
K1069 Ubiquitination PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
Y1166 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus   RLIMS-P 27788493, 23899556
C1173 Methylation IEDB 31844290
S1179 Phosphorylation PhosphoSitePlus
S1182 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus
S1200 Phosphorylation PhosphoSitePlus   UniProt 24275569
R1209 Methylation PhosphoSitePlus
K1249 Ubiquitination PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
C1266 Methylation IEDB 31844290
S1272 Phosphorylation PhosphoSitePlus
S1382 O-Glycosylation GlyGen 35132862, 29351928
Y1442 Phosphorylation PhosphoSitePlus
K1500 Ubiquitination PhosphoSitePlus
T1525 Phosphorylation PhosphoSitePlus
C1572 Methylation IEDB 31844290
C1651 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
Y406 Phosphorylation HPRD 17322306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C52 Y52 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S310 R310 Biomuta DOID:3571 / liver cancer [ cosmic ]
S319 A319 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K482 M482 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K537 N537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K642 T642 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T704 M704 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
C901 Y901 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1125 F1125 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1191 C1191 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1209 W1209 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1249 M1249 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1272 R1272 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1382 F1382 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1525 A1525 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C1572 W1572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]