Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TCT8 / SPP2A_HUMAN
Protein Name Signal peptide peptidase-like 2A precursor
Gene Name Name: SPPL2A
Synonyms:IMP3;ORFNames:PSEC0147;
Organism Homo sapiens (Human)

PRO ID PR:Q8TCT8
DAG View
PRO Name signal peptide peptidase-like 2A (human)
Definition A signal peptide peptidase-like 2A that is encoded in the genome of human.
Short Label hSPPL2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TCT8 (SPPL2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S94 Phosphorylation HPRD 20068231
K100 Ubiquitination PhosphoSitePlus
N149 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N155 N-Glycosylation GlyGen   UniProt 29741879, 19139490, 24190977
K382 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N155 Y155 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
N155 K155 Biomuta DOID:3571 / liver cancer [ icgc ]