iPTMnet Report for Q8TCT7 (SPPL2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TCT7 / SPP2B_HUMAN
Protein Name Signal peptide peptidase-like 2B precursor
Gene Name Name: SPPL2B
Synonyms:IMP4;
Organism Homo sapiens (Human)

PRO ID PR:Q8TCT7
DAG View
PRO Name signal peptide peptidase-like 2B (human)
Definition A signal peptide peptidase-like 2B that is encoded in the genome of human.
Short Label hSPPL2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TCT7 (SPPL2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T71 O-Glycosylation GlyGen 35289036
S73 O-Glycosylation GlyGen 35289036
K103 Ubiquitination PhosphoSitePlus
N129 N-Glycosylation GlyGen 24190977
T131 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T508 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T71 M71 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S73 Y73 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S385 L385 Biomuta DOID:4159 / skin cancer [ cosmic ]