iPTMnet Report for Q8TBC4 (UBA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TBC4 / UBA3_HUMAN
Protein Name NEDD8-activating enzyme E1 catalytic subunit
Gene Name Name: UBA3
Synonyms:UBE1C;
Organism Homo sapiens (Human)

PRO ID PR:Q8TBC4
DAG View
PRO Name NEDD8-activating enzyme E1 catalytic subunit (human)
Definition A NEDD8-activating enzyme E1 catalytic subunit that is encoded in the genome of human.
Short Label hUBA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TBC4 (UBA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K9 Methylation PhosphoSitePlus
K10 Methylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
R135 Methylation PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
K207 Sumoylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
C249 Methylation IEDB 31844290
K260 Ubiquitination PhosphoSitePlus
K284 Sumoylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
R295 Methylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K409 Acetylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S91 Phosphorylation HPRD 20068231
T390 Phosphorylation HPRD 18212344
S399 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation HPRD 20068231
T376 Phosphorylation HPRD 18212344
S385 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 N9 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K147 N147 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K147 T147 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C249 Y249 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K307 N307 Biomuta DOID:1324 / lung cancer [ cosmic ]
S385 F385 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S399 F399 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K434 N434 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]