iPTMnet Report for Q8TB45 (DEPTOR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TB45 / DPTOR_HUMAN
Protein Name DEP domain-containing mTOR-interacting protein
Gene Name Name: DEPTOR
Synonyms:DEPDC6;
Organism Homo sapiens (Human)

PRO ID PR:Q8TB45
DAG View
PRO Name DEP domain-containing mTOR-interacting protein (human)
Definition A DEP domain-containing mTOR-interacting protein that is encoded in the genome of human.
Short Label hDEPTOR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TB45 (DEPTOR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S6 Phosphorylation PhosphoSitePlus
T7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T149 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 22017875
K160 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 35216969
S237 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus   UniProt 19446321
S244 Phosphorylation PhosphoSitePlus   UniProt 19446321, 23186163
S258 Phosphorylation PhosphoSitePlus   UniProt 19446321
T259 Phosphorylation PhosphoSitePlus   UniProt 19446321
S260 Phosphorylation PhosphoSitePlus
S263 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   UniProt 19446321, 22017875
S265 Phosphorylation P42345 (MTOR) PhosphoSitePlus   UniProt 19446321, 22017875
S267 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus   UniProt 19446321
S283 Phosphorylation PhosphoSitePlus   UniProt 19446321
S286 Phosphorylation P42345 (MTOR) , Q15418 (RPS6KA1) , P23443 (RPS6KB1) , P48729 (CSNK1A1) PhosphoSitePlus   Signor   UniProt 22017875, 22017877, 22017876
S287 Phosphorylation Q15418 (RPS6KA1) , P48729 (CSNK1A1) , P23443 (RPS6KB1) PhosphoSitePlus   Signor   UniProt 22017875, 19446321, 22017877, ...22017876
Y289 Phosphorylation PhosphoSitePlus   UniProt 34634301
S291 Phosphorylation P48729 (CSNK1A1) , P23443 (RPS6KB1) , Q15418 (RPS6KA1) PhosphoSitePlus   Signor   UniProt 22017877, 22017876
S292 Phosphorylation PhosphoSitePlus
S293 Phosphorylation P42345 (MTOR) PhosphoSitePlus   Signor   UniProt 22017875, 22017877, 19446321
T295 Phosphorylation P42345 (MTOR) PhosphoSitePlus   UniProt 22017875
S297 Phosphorylation PhosphoSitePlus   UniProt 19446321
S298 Phosphorylation PhosphoSitePlus   UniProt 19446321
S299 Phosphorylation P42345 (MTOR) neXtProt   PhosphoSitePlus   Signor   UniProt 22017875, 22017877, 19446321
K311 Ubiquitination PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18491316
S265 Phosphorylation HPRD 18767875


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8TB45 (DEPTOR) S235 Q93009 (USP7) unknown eFIP 35216969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K131 N131 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K160 E160 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S244 N244 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S260 I260 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S265 N265 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S282 G282 Biomuta DOID:1324 / lung cancer [ cosmic ]
S286 I286 Biomuta DOID:3571 / liver cancer [ cosmic ]
S298 N298 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T321 I321 Biomuta DOID:4159 / skin cancer [ cosmic ]
S389 N389 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ]