Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TAP9 / MPLKI_HUMAN
Protein Name M-phase-specific PLK1-interacting protein
Gene Name Name: MPLKIP
Synonyms:C7orf11,TTDN1;
Organism Homo sapiens (Human)

PRO ID PR:Q8TAP9
DAG View
PRO Name M-phase-specific PLK1-interacting protein (human)
Definition An M-phase-specific PLK1-interacting protein that is encoded in the genome of human.
Short Label hMPLKIP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TAP9 (MPLKIP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
Y13 Phosphorylation HPRD   PhosphoSitePlus 18691976
S23 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
R28 Methylation PhosphoSitePlus
R37 Methylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus   UniProt 23186163
R42 Methylation PhosphoSitePlus
Y45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 18220336
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
T51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
Y54 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
R57 Methylation PhosphoSitePlus   UniProt 24129315
R59 Methylation PhosphoSitePlus   UniProt 24129315
S66 Phosphorylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus   UniProt 24129315
S72 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
R77 Methylation PhosphoSitePlus   UniProt 24129315
S80 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
S82 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 20068231
S91 Phosphorylation PhosphoSitePlus
R92 Methylation PhosphoSitePlus
S93 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17310276, 18669648, 20068231, ...18691976
S97 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation HPRD 18691976
S104 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 18669648, 20068231, ...17310276
T110 Phosphorylation PhosphoSitePlus
S115 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
R117 Methylation PhosphoSitePlus   UniProt 24129315
S119 Phosphorylation PhosphoSitePlus
T120 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 16964243, 17310276, ...18669648, 20068231
S124 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R126 Methylation PhosphoSitePlus
S133 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 19664994, ...19651622, 20068231
K173 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T10 A10 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
R42 P42 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S72 N72 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y103 * Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S119 C119 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
T120 K120 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R126 H126 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R126 C126 Biomuta DOID:363 / uterine cancer [ tcga ]
S133 C133 Biomuta DOID:0070003 / blastoma [ cosmic ]