iPTMnet Report for Q8NI27 (THOC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NI27 / THOC2_HUMAN
Protein Name THO complex subunit 2
Gene Name Name: THOC2
Synonyms:CXorf3;
Organism Homo sapiens (Human)

PRO ID PR:Q8NI27
DAG View
PRO Name THO complex subunit 2 (human)
Definition A THO complex subunit 2 that is encoded in the genome of human.
Short Label hTHOC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NI27 (THOC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y54 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
Y517 Phosphorylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
Y590 Phosphorylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
S600 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34019948, 28510447, 33465208
S600 Phosphorylation PhosphoSitePlus
C646 Methylation IEDB 31844290
S673 Phosphorylation PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
C743 Methylation IEDB 31844290
K761 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K923 Acetylation PhosphoSitePlus
K928 Acetylation PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
C996 Methylation IEDB 31844290
K1007 Ubiquitination PhosphoSitePlus
C1031 Methylation IEDB 31844290
S1055 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34019948, 28510447, 33465208
T1059 O-Glycosylation GlyGen 33465208
K1062 Ubiquitination PhosphoSitePlus
K1084 Ubiquitination PhosphoSitePlus
Y1090 Phosphorylation PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
K1103 Acetylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
K1136 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
S1215 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
K1239 Acetylation PhosphoSitePlus
S1245 O-Glycosylation GlyGen 33214551, 30379171, 29351928, ...34019948, 28510447, 33465208
S1246 O-Glycosylation GlyGen 33465208
T1247 O-Glycosylation GlyGen 33465208
T1248 O-Glycosylation GlyGen 33465208
T1285 Phosphorylation PhosphoSitePlus
T1288 Phosphorylation PhosphoSitePlus
T1289 Phosphorylation PhosphoSitePlus
K1328 Acetylation PhosphoSitePlus
K1336 Acetylation PhosphoSitePlus
T1344 Phosphorylation PhosphoSitePlus
T1345 Phosphorylation PhosphoSitePlus
S1351 Phosphorylation PhosphoSitePlus
K1352 Ubiquitination PhosphoSitePlus
S1353 Phosphorylation PhosphoSitePlus
T1354 Phosphorylation PhosphoSitePlus
S1364 Phosphorylation IEDB   PhosphoSitePlus 27920218
T1385 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1388 Phosphorylation PhosphoSitePlus
S1390 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1393 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T1414 Phosphorylation PhosphoSitePlus
S1417 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
S1419 Phosphorylation PhosphoSitePlus
S1421 Phosphorylation PhosphoSitePlus
S1422 Phosphorylation PhosphoSitePlus
K1432 Ubiquitination PhosphoSitePlus
K1437 Ubiquitination PhosphoSitePlus
Y1439 Phosphorylation PhosphoSitePlus
T1443 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1448 Phosphorylation PhosphoSitePlus
S1450 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1467 Phosphorylation PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
T1497 Phosphorylation PhosphoSitePlus
K1498 Ubiquitination PhosphoSitePlus
S1510 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
S1516 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1520 Phosphorylation PhosphoSitePlus
Y1522 Phosphorylation PhosphoSitePlus
S1547 Phosphorylation PhosphoSitePlus
S1555 Phosphorylation PhosphoSitePlus
S1576 Phosphorylation PhosphoSitePlus
S1577 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1217 Phosphorylation HPRD 18452278
S1222 Phosphorylation HPRD 20068231
T1224 Phosphorylation HPRD 20068231
T1289 Phosphorylation HPRD 16964243
S1364 Phosphorylation HPRD 17081983, 20068231
T1385 Phosphorylation HPRD 18669648, 20068231
S1388 Phosphorylation HPRD 20068231
S1390 Phosphorylation HPRD 18767875, 18669648, 20068231
S1393 Phosphorylation HPRD 18669648, 20068231
T1414 Phosphorylation HPRD 18691976, 20068230
S1417 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
S1419 Phosphorylation HPRD 19651622, 18669648
S1421 Phosphorylation HPRD 18669648
S1422 Phosphorylation HPRD 20068231, 18452278
T1443 Phosphorylation HPRD 18669648, 17081983, 20068231, ...17924679
S1448 Phosphorylation HPRD 18669648, 17081983, 20068231
S1450 Phosphorylation HPRD 18669648, 20068231
S1467 Phosphorylation HPRD 20068231
S1486 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
T1497 Phosphorylation HPRD 19651622, 20068231
S1516 Phosphorylation HPRD 19413330, 18767875, 19664994, ...20068231
S1520 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K154 E154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K154 N154 Biomuta DOID:1324 / lung cancer [ cosmic ]
K345 Q345 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S423 G423 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y590 C590 Biomuta DOID:363 / uterine cancer [ icgc ]
C743 F743 Biomuta DOID:1612 / breast cancer [ cosmic ]
S799 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K923 R923 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K928 N928 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1062 N1062 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1103 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1108 L1108 Biomuta DOID:363 / uterine cancer [ icgc ]
K1136 Q1136 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1136 N1136 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1217 F1217 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S1219 L1219 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S1222 I1222 Biomuta DOID:363 / uterine cancer [ icgc ]
S1222 R1222 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1345 A1345 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K1352 Q1352 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1353 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1364 P1364 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1388 T1388 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1388 Y1388 Biomuta DOID:363 / uterine cancer [ icgc ]
S1422 P1422 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1432 N1432 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1510 L1510 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1516 T1516 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1547 Y1547 Biomuta DOID:363 / uterine cancer [ icgc ]
S1555 F1555 Biomuta DOID:4159 / skin cancer [ cosmic ]