iPTMnet Report for Q8NHY2 (COP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NHY2 / COP1_HUMAN
Protein Name E3 ubiquitin-protein ligase COP1
Gene Name Name: COP1
Synonyms:RFWD2;
Organism Homo sapiens (Human)

PRO ID PR:Q8NHY2
DAG View
PRO Name E3 ubiquitin-protein ligase COP1 (human)
Definition An E3 ubiquitin-protein ligase COP1 that is encoded in the genome of human.
Short Label hCOP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NHY2 (COP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
S387 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20843328, 25957415, 16931761
K398 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
C632 Methylation IEDB 31844290
K684 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S387 Phosphorylation PRO 20843328


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026848 (hCOP1/Phos:1) pS387 PRO 20843328


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P43268 (ETV4) S73 Q8NHY2 (COP1) inhibited_association eFIP 28373072
Phosphorylation Q8NHY2 (COP1) S387 P04637 (TP53) inhibited_association eFIP 16931761


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000026848 (hCOP1/Phos:1) Interaction PR:O70456 (mSFN) PRO 20843328


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K294 N294 Biomuta DOID:1324 / lung cancer [ cosmic ]
K294 Q294 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K345 E345 Biomuta DOID:1324 / lung cancer [ cosmic ]
K398 R398 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K555 N555 Biomuta DOID:1324 / lung cancer [ cosmic ]