iPTMnet Report for Q8NHG8 (ZNRF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NHG8 / ZNRF2_HUMAN
Protein Name E3 ubiquitin-protein ligase ZNRF2
Gene Name Name: ZNRF2
Synonyms:RNF202;
Organism Homo sapiens (Human)

PRO ID PR:Q8NHG8
DAG View
PRO Name E3 ubiquitin-protein ligase ZNRF2 (human)
Definition An E3 ubiquitin-protein ligase ZNRF2 that is encoded in the genome of human.
Short Label hZNRF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NHG8 (ZNRF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 14561866, 22797923
S6 Phosphorylation PhosphoSitePlus
Y18 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 27244671, 18220336, ...19648646, 19664994, 22797923, 18669648, 20166139
S21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T34 Phosphorylation PhosphoSitePlus
S55 O-Glycosylation GlyGen 31373491
S60 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S82 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18212344, ...18220336, 19651622, 22797923, 18669648, 24275569, 20166139, 19690332, 20068231
S89 Phosphorylation PhosphoSitePlus   UniProt 24275569
S92 Phosphorylation PhosphoSitePlus
S106 Phosphorylation HPRD   phospho.ELM 18669648
S107 Phosphorylation HPRD   phospho.ELM 18669648
S108 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y111 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S113 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 19690332
S116 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18669648, 19690332
S119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18669648
S120 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S135 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 19651622, 24275569, 20068231
S145 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 27244671, 20068231, ...22797923
S151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231
K165 Ubiquitination PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S60 G60 Biomuta [ cosmic ]
S92 P92 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K165 T165 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]