iPTMnet Report for Q8NG66 (NEK11)
Protein Information
| UniProt AC / UniProt ID | Q8NG66 / NEK11_HUMAN |
| Protein Name | Serine/threonine-protein kinase Nek11 |
| Gene Name | Name: NEK11 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8NG66 |
| PRO Name | serine/threonine-protein kinase Nek11 (human) |
| Definition | A serine/threonine-protein kinase Nek11 that is encoded in the genome of human. |
| Short Label | hNEK11 |
| Category | organism-gene |
DAG ViewQ8NG66 (NEK11) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y29 | Phosphorylation | score1 | IEDB | 35494241 | ||
| Y44 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S84 | Phosphorylation | score1 | IEDB | 35494241 | ||
| K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S273 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20090422, 19734889 | ||
| S273 | Phosphorylation | O14757 (CHEK1) | score3 | neXtProt PhosphoSitePlus Signor | 19734889 | |
| K312 | Acetylation | score1 | PhosphoSitePlus | |||
| S387 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T585 | Phosphorylation | score1 | PhosphoSitePlus |
Q8NG66 (NEK11) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P30304 (CDC25A) | S79 | score3 | neXtProt PhosphoSitePlus | 19734889 | |
| P30304 (CDC25A) | S82 | score3 | neXtProt PhosphoSitePlus Signor | 19734889 | |
| P30304 (CDC25A) | S88 | score3 | neXtProt PhosphoSitePlus Signor | 19734889 | |
| P54132 (BLM) | S338 | score2 | PhosphoSitePlus | 24239288 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S273 | L273 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S387 | C387 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] |
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