iPTMnet Report for Q8NG31 (KNL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NG31 / KNL1_HUMAN
Protein Name Kinetochore scaffold 1
Gene Name Name: KNL1
Synonyms:CASC5,KIAA1570;
Organism Homo sapiens (Human)

PRO ID PR:Q8NG31
DAG View
PRO Name kinetochore scaffold 1 (human)
Definition A kinetochore scaffold 1 that is encoded in the genome of human.
Short Label hKNL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NG31 (KNL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   RLIMS-P   Signor 20471944, 29142109
S25 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S32 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163, ...16565220
S60 Phosphorylation Q96GD4 (AURKB) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20471944, 23186163, 32027339, ...16565220, 22067460, 18669648, 29142109
K75 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
C130 Methylation IEDB 31844290
K150 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T158 O-Glycosylation GlyGen 30379171, 35254053, 34019948, ...30059200, 35132862, 28510447
K199 Ubiquitination PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K252 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S425 O-Glycosylation GlyGen 30059200
T438 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
T513 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648
K514 Ubiquitination PhosphoSitePlus
T517 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648
K526 Sumoylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
T539 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163, 20068231
K557 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus   UniProt 23186163
S584 Phosphorylation PhosphoSitePlus   UniProt 23186163
T586 Phosphorylation PhosphoSitePlus   UniProt 23186163
K589 Ubiquitination PhosphoSitePlus
S633 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S634 Phosphorylation PhosphoSitePlus
S635 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T642 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K657 Sumoylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
T714 O-Glycosylation GlyGen 30379171, 35254053, 34019948, ...30059200, 35132862, 28510447
S716 O-Glycosylation GlyGen 30379171, 35254053, 34019948, ...30059200, 35132862, 28510447
S720 O-Glycosylation GlyGen 30379171, 35254053, 34019948, ...30059200, 35132862, 28510447
K726 Ubiquitination PhosphoSitePlus
S731 O-Glycosylation GlyGen 30379171, 35254053, 34019948, ...30059200, 35132862, 28510447
K737 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
S765 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S767 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220
T770 Phosphorylation PhosphoSitePlus
Y773 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
K830 Acetylation PhosphoSitePlus
K830 Sumoylation PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
K841 Ubiquitination PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
T943 Phosphorylation PhosphoSitePlus   RLIMS-P 29142109
K953 Ubiquitination PhosphoSitePlus
S956 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220, 22067460, ...18669648, 20068231
S1004 Phosphorylation PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
T1011 Phosphorylation PhosphoSitePlus
T1013 Phosphorylation PhosphoSitePlus
T1017 Phosphorylation PhosphoSitePlus
T1019 Phosphorylation PhosphoSitePlus
S1039 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
T1042 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648, 16565220
K1064 Ubiquitination PhosphoSitePlus
K1069 Ubiquitination PhosphoSitePlus
K1072 Sumoylation PhosphoSitePlus
K1072 Ubiquitination PhosphoSitePlus
S1076 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16565220, ...22067460, 18669648, 19690332, 20068231
S1085 Phosphorylation phospho.ELM 18669648
S1086 Phosphorylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1093 Phosphorylation PhosphoSitePlus
K1100 Ubiquitination PhosphoSitePlus
T1155 Phosphorylation PhosphoSitePlus   RLIMS-P 29142109
K1165 Ubiquitination PhosphoSitePlus
K1214 Ubiquitination PhosphoSitePlus
K1221 Ubiquitination PhosphoSitePlus
K1229 Ubiquitination PhosphoSitePlus
S1232 Phosphorylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
K1248 Ubiquitination PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
T1263 Phosphorylation PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
K1281 Ubiquitination PhosphoSitePlus
K1285 Ubiquitination PhosphoSitePlus
K1295 Ubiquitination PhosphoSitePlus
K1393 Ubiquitination PhosphoSitePlus
K1402 Ubiquitination PhosphoSitePlus
K1413 Ubiquitination PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
Y1432 Phosphorylation PhosphoSitePlus
K1441 Ubiquitination PhosphoSitePlus
S1448 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1450 Ubiquitination PhosphoSitePlus
K1453 Ubiquitination PhosphoSitePlus
K1457 Ubiquitination PhosphoSitePlus
Y1459 Phosphorylation PhosphoSitePlus
Y1464 Phosphorylation PhosphoSitePlus
K1480 Ubiquitination PhosphoSitePlus
K1481 Ubiquitination PhosphoSitePlus
K1488 Ubiquitination PhosphoSitePlus
S1494 Phosphorylation PhosphoSitePlus
K1495 Ubiquitination PhosphoSitePlus
K1499 Ubiquitination PhosphoSitePlus
S1500 Phosphorylation PhosphoSitePlus
K1515 Sumoylation PhosphoSitePlus
K1515 Ubiquitination PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
K1530 Acetylation PhosphoSitePlus
K1530 Ubiquitination PhosphoSitePlus
K1534 Ubiquitination PhosphoSitePlus
K1584 Ubiquitination PhosphoSitePlus
K1642 Ubiquitination PhosphoSitePlus
S1652 Phosphorylation PhosphoSitePlus
S1660 Phosphorylation PhosphoSitePlus
K1670 Methylation PhosphoSitePlus
S1675 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S1690 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1692 Phosphorylation phospho.ELM 18669648
K1718 Ubiquitination PhosphoSitePlus
S1724 Phosphorylation PhosphoSitePlus
Y1736 Phosphorylation PhosphoSitePlus
K1770 Ubiquitination PhosphoSitePlus
S1773 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 27920218, 18669648, 16565220
K1778 Ubiquitination PhosphoSitePlus
T1814 Phosphorylation PhosphoSitePlus
T1824 Phosphorylation PhosphoSitePlus
K1830 Ubiquitination PhosphoSitePlus
S1831 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1834 Phosphorylation PhosphoSitePlus
K1838 Ubiquitination PhosphoSitePlus
S1841 Phosphorylation PhosphoSitePlus
T1843 Phosphorylation PhosphoSitePlus
S1845 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163
S1846 Phosphorylation PhosphoSitePlus
S1848 Phosphorylation PhosphoSitePlus
S1849 Phosphorylation PhosphoSitePlus
S1850 Phosphorylation PhosphoSitePlus
K1855 Ubiquitination PhosphoSitePlus
S1860 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1879 Phosphorylation PhosphoSitePlus
K1888 Ubiquitination PhosphoSitePlus
S1915 Phosphorylation PhosphoSitePlus
T1925 Phosphorylation PhosphoSitePlus
K1942 Ubiquitination PhosphoSitePlus
K1961 Ubiquitination PhosphoSitePlus
K1969 Ubiquitination PhosphoSitePlus
K1976 Ubiquitination PhosphoSitePlus
K1981 Ubiquitination PhosphoSitePlus
S1986 Phosphorylation PhosphoSitePlus
Y1996 Phosphorylation PhosphoSitePlus
K2001 Acetylation PhosphoSitePlus
K2009 Ubiquitination PhosphoSitePlus
K2016 Acetylation PhosphoSitePlus
K2016 Ubiquitination PhosphoSitePlus
K2022 Ubiquitination PhosphoSitePlus
K2033 Ubiquitination PhosphoSitePlus
K2037 Ubiquitination PhosphoSitePlus
K2043 Ubiquitination PhosphoSitePlus
K2047 Ubiquitination PhosphoSitePlus
S2076 Phosphorylation PhosphoSitePlus
K2083 Ubiquitination PhosphoSitePlus
K2089 Sumoylation PhosphoSitePlus
K2089 Ubiquitination PhosphoSitePlus
T2090 Phosphorylation PhosphoSitePlus
K2106 Ubiquitination PhosphoSitePlus
K2118 Ubiquitination PhosphoSitePlus
K2214 Ubiquitination PhosphoSitePlus
K2247 Ubiquitination PhosphoSitePlus
K2324 Ubiquitination PhosphoSitePlus
K2328 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T875 Phosphorylation PR:P33981 (hTTK) PRO   PhosphoSitePlus 22660415
S1022 Phosphorylation PR:P33981 (hTTK) PRO 22660415
S1037 Phosphorylation PR:P33981 (hTTK) PRO 22660415
T1075 Phosphorylation PR:P33981 (hTTK) PRO 22660415
T1089 Phosphorylation PR:P33981 (hTTK) PRO 22660415
T1129 Phosphorylation PR:P33981 (hTTK) PRO 22660415
T1154 Phosphorylation PR:P33981 (hTTK) PRO 22660415
T1167 Phosphorylation PR:P33981 (hTTK) PRO 22660415


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000035558 (hKNL1/iso:2/Phos:1) pT875,pS1022,pS1037,pT1075,pT1089,pT1129,pT1154,pT1167 PR:P33981 (hTTK) PRO 22660415


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14777 (hNDC80) Interaction PR:Q8NG31 (hKNL1) PRO
PR:O43683 (hBUB1) Interaction PR:Q8NG31 (hKNL1) PRO
PR:O60566 (hBUB1B) Interaction PR:Q8NG31 (hKNL1) PRO
PR:Q8NG31 (hKNL1) Interaction PR:O60566 (hBUB1B) PRO
PR:Q8NG31 (hKNL1) Interaction PR:O14777 (hNDC80) PRO
PR:Q8NG31 (hKNL1) Interaction PR:O43683 (hBUB1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 C32 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S32 N32 Biomuta DOID:363 / uterine cancer [ icgc ]
S60 N60 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K75 N75 Biomuta DOID:4159 / skin cancer [ cosmic ]
S80 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y129 H129 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K223 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y270 S270 Biomuta DOID:4159 / skin cancer [ cosmic ]
S405 F405 Biomuta DOID:4159 / skin cancer [ cosmic ]
S425 L425 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K480 M480 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y489 C489 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T499 I499 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K570 N570 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S578 P578 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S634 F634 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S682 Y682 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T714 A714 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S756 Y756 Biomuta DOID:363 / uterine cancer [ icgc ]
Y773 C773 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S837 G837 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S837 N837 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1004 F1004 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1008 N1008 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1037 A1037 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1039 N1039 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1085 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T1129 I1129 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1154 I1154 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1155 I1155 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1165 R1165 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K1214 T1214 Biomuta DOID:363 / uterine cancer [ icgc ]
K1285 E1285 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K1453 N1453 Biomuta DOID:363 / uterine cancer [ icgc ]
S1494 F1494 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1584 R1584 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1675 Y1675 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1855 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1915 I1915 Biomuta DOID:363 / uterine cancer [ icgc ]
K1942 N1942 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1996 C1996 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2090 N2090 Biomuta DOID:1319 / brain cancer [ cosmic ]
K2247 N2247 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]