iPTMnet Report for Q8NG27 (PJA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NG27 / PJA1_HUMAN
Protein Name E3 ubiquitin-protein ligase Praja-1
Gene Name Name: PJA1
Synonyms:RNF70;
Organism Homo sapiens (Human)

PRO ID PR:Q8NG27
DAG View
PRO Name E3 ubiquitin-protein ligase Praja-1 (human)
Definition An E3 ubiquitin-protein ligase Praja-1 that is encoded in the genome of human.
Short Label hPJA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NG27 (PJA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S202 O-Glycosylation GlyGen 30620550
S265 O-Glycosylation GlyGen 30379171
S265 Phosphorylation PhosphoSitePlus   UniProt 23186163
T277 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
C613 Methylation IEDB 31844290
K628 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S70 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
S70 Phosphorylation HPRD 19664995
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 19664995


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96RK0 (CIC) S173 Q8NG27 (PJA1) decreased_association eFIP 30737375


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S314 I314 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S392 G392 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S448 Y448 Biomuta DOID:363 / uterine cancer [ icgc ]
C613 Y613 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]