iPTMnet Report for Q8NG08 (HELB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NG08 / HELB_HUMAN
Protein Name DNA helicase B
Gene Name Name: HELB
Organism Homo sapiens (Human)

PRO ID PR:Q8NG08
DAG View
PRO Name DNA helicase B (human)
Definition A DNA helicase B that is encoded in the genome of human.
Short Label hHELB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NG08 (HELB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S64 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
T640 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S967 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 15146062
S979 Phosphorylation PhosphoSitePlus
T980 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
T1027 Phosphorylation PhosphoSitePlus   UniProt 19690332
T1040 Phosphorylation PhosphoSitePlus
S1048 Phosphorylation PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1062 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S709 Phosphorylation HPRD 17525332
S967 Phosphorylation HPRD 19413330, 19664995
S1021 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K143 T143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S235 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K336 T336 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S467 C467 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K651 E651 Biomuta DOID:3571 / liver cancer [ icgc ]
S709 Y709 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K737 N737 Biomuta [ cosmic ]
K779 E779 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S967 F967 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S979 N979 Biomuta DOID:363 / uterine cancer [ icgc ]
S979 I979 Biomuta DOID:1324 / lung cancer [ tcga ]
T980 I980 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S1021 L1021 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]