iPTMnet Report for Q8NFZ0 (FBH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFZ0 / FBH1_HUMAN
Protein Name F-box DNA helicase 1
Gene Name Name: FBH1
Synonyms:FBX18,FBXO18;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFZ0
DAG View
PRO Name F-box DNA helicase 1 (human)
Definition An F-box DNA helicase 1 that is encoded in the genome of human.
Short Label hFBH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFZ0 (FBH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S113 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
K994 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S124 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 L113 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K469 N469 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K475 N475 Biomuta DOID:3571 / liver cancer [ cosmic ]
K479 Q479 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K741 E741 Biomuta DOID:1324 / lung cancer [ cosmic ]
K741 R741 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K836 N836 Biomuta DOID:363 / uterine cancer [ icgc ]