iPTMnet Report for Q8NFU7 (TET1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFU7 / TET1_HUMAN
Protein Name Methylcytosine dioxygenase TET1
Gene Name Name: TET1
Synonyms:CXXC6,KIAA1676,LCX;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFU7
DAG View
PRO Name methylcytosine dioxygenase TET1 (human)
Definition A methylcytosine dioxygenase TET1 that is encoded in the genome of human.
Short Label hTET1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFU7 (TET1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
T858 O-Glycosylation GlyGen 24394411, 28411811, 27259240, ...29351928
S864 O-Glycosylation GlyGen 24394411, 28411811, 27259240, ...29351928
S871 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y935 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
K1161 Acetylation PhosphoSitePlus
T1164 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
T1234 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
T1382 Phosphorylation PhosphoSitePlus
S1492 O-Glycosylation GlyGen 24394411, 28411811, 27259240, ...29351928
K1589 Ubiquitination PhosphoSitePlus   UniProt 36056023
Y1641 Phosphorylation PhosphoSitePlus
S1731 Phosphorylation PhosphoSitePlus
K1769 Ubiquitination PhosphoSitePlus
S1851 Phosphorylation PhosphoSitePlus
T1867 Phosphorylation PhosphoSitePlus
S1971 Phosphorylation PhosphoSitePlus
S1976 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S871 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 G45 Biomuta [ cosmic ]
S116 F116 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S193 T193 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S322 Y322 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S805 C805 Biomuta DOID:1612 / breast cancer [ cosmic ]
S806 F806 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1161 N1161 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T1164 I1164 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1731 Y1731 Biomuta DOID:363 / uterine cancer [ icgc ]
S1976 C1976 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1976 F1976 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1976 Y1976 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]