iPTMnet Report for Q8NFT8 (DNER)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFT8 / DNER_HUMAN
Protein Name Delta and Notch-like epidermal growth factor-related receptor precursor
Gene Name Name: DNER
Synonyms:BET;ORFNames:UNQ262/PRO299;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFT8
DAG View
PRO Name delta and Notch-like epidermal growth factor-related receptor (human)
Definition A delta and Notch-like epidermal growth factor-related receptor that is encoded in the genome of human.
Short Label hDNER
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFT8 (DNER) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S169 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T172 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T174 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T177 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N223 N-Glycosylation GlyGen   UniProt 23090970, 16740002, 24190977
N361 N-Glycosylation GlyGen 23090970, 24190977
Y677 Phosphorylation PhosphoSitePlus
Y681 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
Y711 Phosphorylation PhosphoSitePlus
S714 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y718 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S722 Phosphorylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O60885 (BRD4) Y98 Q8NFT8 (DNER) decreased_association eFIP 34290255


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T172 M172 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T174 K174 Biomuta DOID:3571 / liver cancer [ cosmic ]
N223 I223 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
N223 K223 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y681 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S685 N685 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S688 R688 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S696 Y696 Biomuta DOID:10534 / stomach cancer [ cosmic ]