iPTMnet Report for Q8NFJ8 (BHLHE22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFJ8 / BHE22_HUMAN
Protein Name Class E basic helix-loop-helix protein 22
Gene Name Name: BHLHE22
Synonyms:BHLHB5,TNRC20;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFJ8
DAG View
PRO Name class E basic helix-loop-helix protein 22 (human)
Definition A class E basic helix-loop-helix protein 22 that is encoded in the genome of human.
Short Label hBHLHE22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFJ8 (BHLHE22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus
C126 Methylation IEDB 31844290
Y129 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C126 Y126 Biomuta DOID:4159 / skin cancer [ cosmic ]
S228 N228 Biomuta DOID:1319 / brain cancer [ cosmic ]
S228 G228 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T285 M285 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]