iPTMnet Report for Q8NFJ5 (GPRC5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NFJ5 / RAI3_HUMAN
Protein Name Retinoic acid-induced protein 3
Gene Name Name: GPRC5A
Synonyms:GPCR5A,RAI3,RAIG1;
Organism Homo sapiens (Human)

PRO ID PR:Q8NFJ5
DAG View
PRO Name retinoic acid-induced protein 3 (human)
Definition A retinoic acid-induced protein 3 that is encoded in the genome of human.
Short Label hGPRC5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NFJ5 (GPRC5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K285 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20068231
S301 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18491316, 18077418, 18452278, ...18669648, 20068231
T306 Phosphorylation PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
T315 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y317 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17389395, 18083107, ...15951569, 25311788
Y320 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 25311788
S321 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
S336 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S345 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16565220, ...18669648, 18452278, 20068231, 17924679
Y347 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17016520, 23186163, 18691976, ...18452278, 18083107, 18669648, 25311788
K348 Ubiquitination PhosphoSitePlus
Y350 Phosphorylation P00533 (EGFR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 25311788, 18452278, ...18691976
K353 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K291 T291 Biomuta DOID:4159 / skin cancer [ cosmic ]
T315 M315 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y320 F320 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K333 N333 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K333 Q333 Biomuta DOID:4159 / skin cancer [ cosmic ]
S336 Y336 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S357 R357 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S357 G357 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]