iPTMnet Report Q8NFG4 FLCN

Protein Information

UniProt AC / UniProt ID	Q8NFG4 / FLCN_HUMAN
Protein Name	Folliculin
Gene Name	Name: FLCN Synonyms:BHD;
Organism	Homo sapiens (Human)

PRO ID	PR:Q8NFG4 DAG View
PRO Name	folliculin (human)
Definition	A folliculin that is encoded in the genome of human.
Short Label	hFLCN
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q8NFG4 (FLCN) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine By position S62 S68 S71 S72 S73 K100 S171 T174 K203 K206 T224 K272 S298 S302 S406 R477 K534 S537 S542 S558 K559 K562 S571	PTM Type Select all Methylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen PhosphoSitePlus RLIMS-P RLIMS-P+ UniProt phospho.ELM	PMID
S62	Phosphorylation	P54646 (PRKAA2)	score4	phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P UniProt	21406692, 23186163, 19914239, ...23874397, 18669648, 28656962, 19695222
S68	Phosphorylation		score1	PhosphoSitePlus
S71	Phosphorylation		score1	PhosphoSitePlus
S72	Phosphorylation		score1	PhosphoSitePlus
S73	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	18669648, 23186163, 23874397, ...28656962
K100	Ubiquitination		score1	PhosphoSitePlus
S171	O-Glycosylation		score1	GlyGen	30379171, 35254053
T174	O-Glycosylation		score1	GlyGen	30379171, 35254053
K203	Ubiquitination		score1	PhosphoSitePlus
K206	Ubiquitination		score1	PhosphoSitePlus
T224	Phosphorylation		score1	PhosphoSitePlus
K272	Ubiquitination		score1	PhosphoSitePlus
S298	Phosphorylation		score1	PhosphoSitePlus
S302	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19695222, 18669648, 23186163
S406	Phosphorylation		score3	PhosphoSitePlus UniProt	25126726
R477	Methylation		score1	PhosphoSitePlus
K534	Ubiquitination		score1	PhosphoSitePlus
S537	Phosphorylation		score3	PhosphoSitePlus UniProt	25126726
S542	Phosphorylation		score3	PhosphoSitePlus UniProt	25126726
S558	Phosphorylation		score1	PhosphoSitePlus
K559	Ubiquitination		score1	PhosphoSitePlus
K562	Ubiquitination		score1	PhosphoSitePlus
S571	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163

Search:

Site Select all By amino acid All Serine By position S62 S71 S72 S73 S302	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S62	Phosphorylation	score0	HPRD	19651622, 18669648, 19664994, ...20068231
S71	Phosphorylation	score0	HPRD	19651622
S72	Phosphorylation	score0	HPRD	19651622
S73	Phosphorylation	score0	HPRD	18669648, 19664994
S302	Phosphorylation	score0	HPRD	19413330, 18669648

Search:

Site Select all By amino acid All Serine By position S62 S71 S72 S73	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S62	Phosphorylation	score0	HPRD	19651622, 18669648, 19664994, ...20068231
S71	Phosphorylation	score0	HPRD	19651622
S72	Phosphorylation	score0	HPRD	19651622
S73	Phosphorylation	score0	HPRD	18669648, 19664994

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q8NFG4 (FLCN)	Site Select all By amino acid All Serine By position S302	Interactant Select all P54646 (PRKAA2)	Association type Select all increased_association	Source Select all eFIP	PMID
	Phosphorylation	Q8NFG4 (FLCN)	S302	P54646 (PRKAA2)	increased_association	eFIP	33981707

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S62 S71 S73 K100 K206 S298 S302 S406 R477 S542 K559	Variant Select all * C302 F542 F71 I62 I73 N206 N298 N406 N559 R206	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S62	I62	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S71	F71	Biomuta	DOID:1319 / brain cancer [ cosmic ]
S73	I73	Biomuta	DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K100	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K206	N206	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K206	R206	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S298	N298	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S302	C302	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S406	N406	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
R477	*	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S542	F542	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K559	N559	Biomuta	DOID:1612 / breast cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q8NFG4 (FLCN)

Protein Information

Interactive Sequence View

Q8NFG4 (FLCN) as Substrate

PTM-dependent PPI

PTM sites affected in variants