iPTMnet Report for Q8NEZ4 (KMT2C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEZ4 / KMT2C_HUMAN
Protein Name Histone-lysine N-methyltransferase 2C
Gene Name Name: KMT2C
Synonyms:HALR,KIAA1506,MLL3;
Organism Homo sapiens (Human)

PRO ID PR:Q8NEZ4
DAG View
PRO Name histone-lysine N-methyltransferase 2C (human)
Definition A histone-lysine N-methyltransferase 2C that is encoded in the genome of human.
Short Label hKMT2C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEZ4 (KMT2C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation PhosphoSitePlus   UniProt 23186163
S46 Phosphorylation PhosphoSitePlus   UniProt 20068231
S68 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus   UniProt 21406692
S111 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus   UniProt 23186163
S116 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
S200 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 24275569
S207 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
K758 Acetylation PhosphoSitePlus   UniProt 19608861
K827 Acetylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
K843 Methylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus   UniProt 23186163
K870 Ubiquitination PhosphoSitePlus
R886 Methylation PhosphoSitePlus
K893 Acetylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
T1043 Phosphorylation PhosphoSitePlus
T1219 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
S1248 Phosphorylation PhosphoSitePlus
S1250 Phosphorylation PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
Y1278 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1307 Phosphorylation PhosphoSitePlus
S1310 Phosphorylation PhosphoSitePlus
T1375 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
S1379 Phosphorylation PhosphoSitePlus
K1380 Ubiquitination PhosphoSitePlus
S1387 Phosphorylation PhosphoSitePlus
Y1395 Phosphorylation PhosphoSitePlus
S1435 Phosphorylation PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus
K1508 Acetylation PhosphoSitePlus   UniProt 19608861
S1602 Phosphorylation PhosphoSitePlus
S1724 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
S1728 O-Glycosylation GlyGen 30379171
S1729 O-Glycosylation GlyGen 30379171
S1733 Phosphorylation PhosphoSitePlus
K1766 Acetylation PhosphoSitePlus
K1772 Acetylation PhosphoSitePlus   UniProt 19608861
T1837 O-Glycosylation GlyGen 32938750
S1840 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...32938750, 34019948, 30059200, 35132862, 31492838, 35254053
S1843 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
S1878 Phosphorylation PhosphoSitePlus
T1904 Phosphorylation PhosphoSitePlus
S1919 Phosphorylation PhosphoSitePlus
S1947 Phosphorylation PhosphoSitePlus
S1981 Phosphorylation PhosphoSitePlus
S1985 Phosphorylation PhosphoSitePlus
S1987 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1996 Ubiquitination PhosphoSitePlus
K2009 Acetylation PhosphoSitePlus   UniProt 19608861
S2011 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
S2011 Phosphorylation PhosphoSitePlus
S2068 Phosphorylation PhosphoSitePlus
S2117 Phosphorylation PhosphoSitePlus
S2132 Phosphorylation PhosphoSitePlus
T2137 Phosphorylation PhosphoSitePlus
R2211 Methylation PhosphoSitePlus
S2215 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
T2224 Phosphorylation PhosphoSitePlus
R2226 Methylation PhosphoSitePlus
R2228 Methylation PhosphoSitePlus
S2230 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...35254053, 34019948, 30059200, 35132862, 31492838, 30620550
T2234 O-Glycosylation GlyGen 32574038
R2235 Methylation PhosphoSitePlus
T2239 Phosphorylation PhosphoSitePlus
R2267 Methylation PhosphoSitePlus
R2277 Methylation IEDB   PhosphoSitePlus 27503676
R2289 Methylation PhosphoSitePlus
S2291 Phosphorylation PhosphoSitePlus
S2302 Phosphorylation PhosphoSitePlus
T2305 Phosphorylation PhosphoSitePlus
S2308 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
R2571 Methylation IEDB   PhosphoSitePlus 27503676
R2596 Methylation PhosphoSitePlus
R2603 Methylation PhosphoSitePlus
R2609 Methylation PhosphoSitePlus
S2751 Phosphorylation PhosphoSitePlus
K2769 Acetylation PhosphoSitePlus
K2795 Acetylation PhosphoSitePlus
K2802 Acetylation PhosphoSitePlus   UniProt 19608861
S2807 Phosphorylation PhosphoSitePlus
K2809 Acetylation PhosphoSitePlus   UniProt 19608861
S2811 Phosphorylation PhosphoSitePlus
K2814 Acetylation PhosphoSitePlus
K2815 Acetylation PhosphoSitePlus
T2817 Phosphorylation PhosphoSitePlus
K2823 Acetylation PhosphoSitePlus
S2828 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2831 O-Glycosylation GlyGen 23301498, 30379171, 32574038, ...34019948, 30059200, 35132862, 31492838, 35254053
K2832 Acetylation PhosphoSitePlus   UniProt 19608861
T2851 Phosphorylation PhosphoSitePlus
S2860 Phosphorylation PhosphoSitePlus
S2930 Phosphorylation phospho.ELM 18669648
S2935 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2937 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2942 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2946 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2948 Phosphorylation PhosphoSitePlus
S2952 Phosphorylation phospho.ELM 18669648
S2977 Phosphorylation IEDB 35494241
S3080 Phosphorylation PhosphoSitePlus
K3210 Acetylation PhosphoSitePlus
S3339 Phosphorylation PhosphoSitePlus
T3362 Phosphorylation PhosphoSitePlus
S3371 Phosphorylation PhosphoSitePlus
S3519 Phosphorylation PhosphoSitePlus
S3526 Phosphorylation PhosphoSitePlus
T3693 Phosphorylation PhosphoSitePlus
K3714 Acetylation PhosphoSitePlus   UniProt 19608861
S3758 Phosphorylation PhosphoSitePlus   UniProt 24275569
S3786 Phosphorylation PhosphoSitePlus
S3788 Phosphorylation PhosphoSitePlus
S3800 Phosphorylation PhosphoSitePlus
K3945 Acetylation PhosphoSitePlus
S3974 Phosphorylation PhosphoSitePlus
T3977 Phosphorylation PhosphoSitePlus
T3997 Phosphorylation PhosphoSitePlus
S4006 Phosphorylation PhosphoSitePlus
Y4018 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S4022 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K4025 Sumoylation PhosphoSitePlus
S4034 Phosphorylation PhosphoSitePlus   UniProt 24275569
S4050 Phosphorylation PhosphoSitePlus
S4071 Phosphorylation PhosphoSitePlus
R4139 Methylation PhosphoSitePlus
R4156 Methylation PhosphoSitePlus
R4162 Methylation PhosphoSitePlus
S4213 Phosphorylation PhosphoSitePlus
K4215 Ubiquitination PhosphoSitePlus
K4222 Ubiquitination PhosphoSitePlus
S4260 Phosphorylation PhosphoSitePlus
S4263 Phosphorylation PhosphoSitePlus
S4267 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S4274 Phosphorylation PhosphoSitePlus
S4300 Phosphorylation PhosphoSitePlus
S4304 Phosphorylation PhosphoSitePlus
S4361 Phosphorylation PhosphoSitePlus
T4370 Phosphorylation PhosphoSitePlus
K4372 Ubiquitination PhosphoSitePlus
Y4526 Phosphorylation PhosphoSitePlus
S4537 Phosphorylation PhosphoSitePlus
S4588 Phosphorylation PhosphoSitePlus
C4883 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation HPRD 20068231
S111 Phosphorylation HPRD 18452278
S113 Phosphorylation HPRD 18452278
S625 Phosphorylation HPRD 18491316
S631 Phosphorylation HPRD 18491316
T1219 Phosphorylation HPRD 20068231
S1493 Phosphorylation HPRD 18452278
T2824 Phosphorylation HPRD 20068231
S2831 Phosphorylation HPRD 20068231
S2930 Phosphorylation HPRD 18669648
S2935 Phosphorylation HPRD 18669648, 20068231
S2937 Phosphorylation HPRD 18669648
T2942 Phosphorylation HPRD 18669648
S2946 Phosphorylation HPRD 18669648, 20068231
S2952 Phosphorylation HPRD 18669648
S4006 Phosphorylation HPRD 18452278
Y4018 Phosphorylation HPRD 17081983
S4022 Phosphorylation HPRD 17081983
S4034 Phosphorylation HPRD 20068231, 18452278
S4227 Phosphorylation HPRD 20068231
S4267 Phosphorylation HPRD 20068231
S4300 Phosphorylation HPRD 20068231
S4304 Phosphorylation HPRD 20068231
T4388 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 Y46 Biomuta DOID:4159 / skin cancer [ cosmic ]
S68 I68 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S68 G68 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S111 F111 Biomuta DOID:4159 / skin cancer [ cosmic ]
S116 L116 Biomuta [ cosmic ]
S119 F119 Biomuta DOID:4159 / skin cancer [ cosmic ]
S177 N177 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic ]
Y181 F181 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S217 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S620 F620 Biomuta DOID:3571 / liver cancer [ cosmic ]
S620 Y620 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S753 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S753 L753 Biomuta DOID:4159 / skin cancer [ cosmic ]
K827 I827 Biomuta DOID:1612 / breast cancer [ cosmic ]
S836 Y836 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S836 C836 Biomuta DOID:1324 / lung cancer [ cosmic ]
S854 R854 Biomuta DOID:1612 / breast cancer [ cosmic ]
R886 C886 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R886 H886 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K893 M893 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1225 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1228 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1248 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1248 L1248 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1250 Y1250 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1250 C1250 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1307 A1307 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1310 Y1310 Biomuta DOID:11615 / penile cancer [ cosmic ]
Y1395 C1395 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1602 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1602 L1602 Biomuta [ cosmic ]
S1733 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1733 L1733 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
T1837 P1837 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1840 C1840 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1904 I1904 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1904 A1904 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1919 C1919 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1947 F1947 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1987 F1987 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2009 N2009 Biomuta DOID:2998 / testicular cancer [ cosmic ]
S2117 F2117 Biomuta DOID:4159 / skin cancer [ cosmic ]
R2211 T2211 Biomuta DOID:184 / bone cancer [ cosmic ]
R2228 M2228 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
R2235 K2235 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2235 S2235 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R2235 M2235 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T2239 A2239 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R2277 W2277 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R2289 H2289 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S2291 F2291 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2308 F2308 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R2571 W2571 Biomuta DOID:1612 / breast cancer [ cosmic ]
R2596 Q2596 Biomuta DOID:1319 / brain cancer [ cosmic ]
R2596 L2596 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2603 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R2603 G2603 Biomuta DOID:1324 / lung cancer [ cosmic ]
R2609 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S2751 A2751 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2751 L2751 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K2769 N2769 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K2809 I2809 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K2814 I2814 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2815 T2815 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2831 Y2831 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2832 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S2860 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S2930 L2930 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S2930 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S2935 L2935 Biomuta DOID:1612 / breast cancer [ cosmic ]
S2937 T2937 Biomuta DOID:1612 / breast cancer [ cosmic ]
S2946 F2946 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2948 A2948 Biomuta DOID:363 / uterine cancer [ icgc ]
S2952 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2977 Y2977 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S3371 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S3371 L3371 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3519 L3519 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K3714 E3714 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3786 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S3786 T3786 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S3788 F3788 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S4022 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S4050 L4050 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S4050 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R4139 Q4139 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R4139 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
R4156 G4156 Biomuta DOID:1324 / lung cancer [ cosmic ]
K4215 N4215 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S4260 C4260 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S4300 A4300 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S4300 Y4300 Biomuta DOID:1319 / brain cancer [ cosmic ]
S4361 C4361 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T4388 P4388 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y4526 C4526 Biomuta DOID:10283 / prostate cancer [ cosmic ]