iPTMnet Report for Q8NEY8 (PPHLN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEY8 / PPHLN_HUMAN
Protein Name Periphilin-1
Gene Name Name: PPHLN1
ORFNames:HSPC206,HSPC232;
Organism Homo sapiens (Human)

PRO ID PR:Q8NEY8
DAG View
PRO Name periphilin-1 (human)
Definition A periphilin-1 that is encoded in the genome of human.
Short Label hPPHLN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEY8 (PPHLN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y9 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
K37 Sumoylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
R43 Methylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
S110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 22267324, ...17287340, 20068231
S110 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
Y112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y116 Phosphorylation PhosphoSitePlus
S121 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T128 Phosphorylation PhosphoSitePlus
S133 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 18669648, 20068231, 17924679
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S143 Phosphorylation PhosphoSitePlus
S145 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K160 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y162 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus   UniProt 20068231
K171 Sumoylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K199 Sumoylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T200 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T204 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S205 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 16964243, ...18669648, 24275569, 20068231, 17081983
S207 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S208 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S210 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus   UniProt 19608861
K235 Sumoylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Acetylation PhosphoSitePlus   UniProt 19608861
K240 Sumoylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
C309 Methylation IEDB 31844290
K322 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus   UniProt 23186163
K328 Sumoylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
K453 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 18212344
S92 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 20068231
S110 Phosphorylation HPRD 17287340, 18212344, 20068231
S121 Phosphorylation HPRD 17287340, 17081983, 20068231
T128 Phosphorylation HPRD 18767875, 17081983, 20068231
S133 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 18669648, 20166139, 18452278, 20068231, 17924679
S140 Phosphorylation HPRD 19651622, 17081983
S143 Phosphorylation HPRD 20068231
S145 Phosphorylation HPRD 17287340
S155 Phosphorylation HPRD 17287340
S161 Phosphorylation HPRD 20068231
S167 Phosphorylation HPRD 20068231
S197 Phosphorylation HPRD 18669648, 20068231
T200 Phosphorylation HPRD 19651622, 18691976, 17287340, ...17081983, 20068231
S201 Phosphorylation HPRD 19413330, 17287340, 17081983
T204 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 20068231
S205 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 19691289, 19664995, 19651622, 18669648, 20068231
S207 Phosphorylation HPRD 19651622, 17287340
S208 Phosphorylation HPRD 17287340
S222 Phosphorylation HPRD 20068231
S244 Phosphorylation HPRD 20058876
S247 Phosphorylation HPRD 20058876
T298 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation PhosphoSitePlus
S61 Phosphorylation HPRD 18212344
S99 Phosphorylation HPRD 20068231
S101 Phosphorylation HPRD 20068231
S117 Phosphorylation HPRD 17287340, 18212344, 20068231
S128 Phosphorylation HPRD 17287340, 17081983, 20068231
T135 Phosphorylation HPRD 18767875, 17081983, 20068231
S140 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 18669648, 20166139, 18452278, 20068231, 17924679
S147 Phosphorylation HPRD 19651622, 17081983
S150 Phosphorylation HPRD 20068231
S152 Phosphorylation HPRD 17287340
S162 Phosphorylation HPRD 17287340
S168 Phosphorylation HPRD 20068231
S174 Phosphorylation HPRD 20068231
S204 Phosphorylation HPRD 18669648, 20068231
T207 Phosphorylation HPRD 19651622, 18691976, 17287340, ...17081983, 20068231
S208 Phosphorylation HPRD 19413330, 17287340, 17081983
T211 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 20068231
S212 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 19691289, 19664995, 19651622, 18669648, 20068231
S214 Phosphorylation HPRD 19651622, 17287340
S215 Phosphorylation HPRD 17287340
S229 Phosphorylation HPRD 20068231
S251 Phosphorylation HPRD 20058876
S254 Phosphorylation HPRD 20058876
T305 Phosphorylation HPRD 20068231
S366 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S44 Phosphorylation HPRD 20068231
S46 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 17287340, 18212344, 20068231
S73 Phosphorylation HPRD 17287340, 17081983, 20068231
T80 Phosphorylation HPRD 18767875, 17081983, 20068231
S85 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 18669648, 20166139, 18452278, 20068231, 17924679
S92 Phosphorylation HPRD 19651622, 17081983
S95 Phosphorylation HPRD 20068231
S97 Phosphorylation HPRD 17287340
S107 Phosphorylation HPRD 17287340
S113 Phosphorylation HPRD 20068231
S119 Phosphorylation HPRD 20068231
S149 Phosphorylation HPRD 18669648, 20068231
T152 Phosphorylation HPRD 19651622, 18691976, 17287340, ...17081983, 20068231
S153 Phosphorylation HPRD 19413330, 17287340, 17081983
T156 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 20068231
S157 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 19691289, 19664995, 19651622, 18669648, 20068231
S159 Phosphorylation HPRD 19651622, 17287340
S160 Phosphorylation HPRD 17287340
S174 Phosphorylation HPRD 20068231
S196 Phosphorylation HPRD 20058876
S199 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 20068231
S46 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 17287340, 18212344, 20068231
S73 Phosphorylation HPRD 17287340, 17081983, 20068231
T80 Phosphorylation HPRD 18767875, 17081983, 20068231
S85 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 18669648, 20166139, 18452278, 20068231, 17924679
S92 Phosphorylation HPRD 19651622, 17081983
S95 Phosphorylation HPRD 20068231
S97 Phosphorylation HPRD 17287340
S107 Phosphorylation HPRD 17287340
S113 Phosphorylation HPRD 20068231
S119 Phosphorylation HPRD 20068231
S149 Phosphorylation HPRD 18669648, 20068231
T152 Phosphorylation HPRD 19651622, 18691976, 17287340, ...17081983, 20068231
S153 Phosphorylation HPRD 19413330, 17287340, 17081983
T156 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 20068231
S157 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 19691289, 19664995, 19651622, 18669648, 20068231
S159 Phosphorylation HPRD 19651622, 17287340
S160 Phosphorylation HPRD 17287340
S174 Phosphorylation HPRD 20068231
S196 Phosphorylation HPRD 20058876
S199 Phosphorylation HPRD 20058876
T250 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 18212344
S92 Phosphorylation HPRD 20068231
S94 Phosphorylation HPRD 20068231
S110 Phosphorylation HPRD 17287340, 18212344, 20068231
S121 Phosphorylation HPRD 17287340, 17081983, 20068231
T128 Phosphorylation HPRD 18767875, 17081983, 20068231
S133 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19691289, 19664995, 19651622, 17322306, 18669648, 20166139, 18452278, 20068231, 17924679
S140 Phosphorylation HPRD 19651622, 17081983
S143 Phosphorylation HPRD 20068231
S145 Phosphorylation HPRD 17287340
S155 Phosphorylation HPRD 17287340
S161 Phosphorylation HPRD 20068231
S167 Phosphorylation HPRD 20068231
S197 Phosphorylation HPRD 18669648, 20068231
T200 Phosphorylation HPRD 19651622, 18691976, 17287340, ...17081983, 20068231
S201 Phosphorylation HPRD 19413330, 17287340, 17081983
T204 Phosphorylation HPRD 19413330, 18691976, 17287340, ...17081983, 20068231
S205 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 19691289, 19664995, 19651622, 18669648, 20068231
S207 Phosphorylation HPRD 19651622, 17287340
S208 Phosphorylation HPRD 17287340
S222 Phosphorylation HPRD 20068231
S244 Phosphorylation HPRD 20058876
S247 Phosphorylation HPRD 20058876
T298 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 T37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S44 C44 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S48 T48 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y52 F52 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S54 R54 Biomuta DOID:263 / kidney cancer [ cosmic ]
S61 R61 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T80 I80 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S92 C92 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S97 C97 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic, cosmic, cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S99 C99 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S107 Y107 Biomuta DOID:4159 / skin cancer [ cosmic ]
S113 F113 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S114 Y114 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y116 D116 Biomuta DOID:363 / uterine cancer [ cosmic ]
T128 I128 Biomuta DOID:1319 / brain cancer [ cosmic ]
T135 I135 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
S145 C145 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T152 A152 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S152 C152 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S153 N153 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S153 L153 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S155 Y155 Biomuta DOID:4159 / skin cancer [ cosmic ]
S162 Y162 Biomuta DOID:4159 / skin cancer [ cosmic ]
S163 F163 Biomuta DOID:4159 / skin cancer [ cosmic ]
S172 F172 Biomuta DOID:4159 / skin cancer [ cosmic ]
T200 A200 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S201 L201 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T207 A207 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S208 L208 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K220 N220 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S329 C329 Biomuta DOID:3571 / liver cancer [ cosmic ]
S366 F366 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]