iPTMnet Report for Q8NEN9 (PDZD8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEN9 / PDZD8_HUMAN
Protein Name PDZ domain-containing protein 8
Gene Name Name: PDZD8
Synonyms:PDZK8;
Organism Homo sapiens (Human)

PRO ID PR:Q8NEN9
DAG View
PRO Name PDZ domain-containing protein 8 (human)
Definition A PDZ domain-containing protein 8 that is encoded in the genome of human.
Short Label hPDZD8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEN9 (PDZD8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S496 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S519 Phosphorylation PhosphoSitePlus
S521 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
T528 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S538 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19664994, ...19651622, 18669648
S603 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
C785 Methylation IEDB 31844290
Y795 Phosphorylation HPRD 18452278
S842 Phosphorylation PhosphoSitePlus
T846 Phosphorylation PhosphoSitePlus
T852 Phosphorylation PhosphoSitePlus
Y856 Phosphorylation PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus
S967 Phosphorylation PhosphoSitePlus   UniProt 23186163
T971 Phosphorylation PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
S989 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K289 N289 Biomuta DOID:363 / uterine cancer [ icgc ]
S519 R519 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S519 I519 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S603 F603 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S663 L663 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S673 L673 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T846 I846 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T852 I852 Biomuta DOID:1324 / lung cancer [ cosmic ]
T974 M974 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S980 G980 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1071 L1071 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]