Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEM2 / SHCBP_HUMAN
Protein Name SHC SH2 domain-binding protein 1
Gene Name Name: SHCBP1
Organism Homo sapiens (Human)

PRO ID PR:Q8NEM2
DAG View
PRO Name SHC SH2 domain-binding protein 1 (human)
Definition An SHC SH2 domain-binding protein 1 that is encoded in the genome of human.
Short Label hSHCBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEM2 (SHCBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895, 20068231
S5 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19691289, 20068231
T7 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S31 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S42 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...22067460, 18669648, 20068231
S44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18767875, 17322306, 22067460, ...18669648, 20068231
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
K51 Ubiquitination PhosphoSitePlus
S54 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648
K64 Sumoylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
C93 Methylation IEDB 31844290
K94 Ubiquitination PhosphoSitePlus
S96 Phosphorylation HPRD   PhosphoSitePlus 20068231
K108 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S269 Phosphorylation HPRD   phospho.ELM 18669648
S273 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 22067460
S275 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K287 Ubiquitination PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y406 Phosphorylation phospho.ELM 16094384
K419 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K567 Sumoylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
T573 Phosphorylation HPRD   phospho.ELM 18669648
S574 Phosphorylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
S634 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17322306, 18669648, 23704356, ...19690332, 20068231
S634 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   Signor 23704356
S647 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y48 C48 Biomuta DOID:1324 / lung cancer [ cosmic ]
K94 R94 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K260 Q260 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K260 N260 Biomuta DOID:363 / uterine cancer [ icgc ]
K287 N287 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K315 N315 Biomuta DOID:363 / uterine cancer [ icgc ]
K488 N488 Biomuta DOID:363 / uterine cancer [ icgc ]
T573 R573 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]