iPTMnet Report for Q8NEM0 (MCPH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEM0 / MCPH1_HUMAN
Protein Name Microcephalin
Gene Name Name: MCPH1
Organism Homo sapiens (Human)

PRO ID PR:Q8NEM0
DAG View
PRO Name microcephalin (human)
Definition A microcephalin that is encoded in the genome of human.
Short Label hMCPH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEM0 (MCPH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   UniProt 23186163
T281 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus   UniProt 23186163
K297 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus   RLIMS-P 25301947
K329 Ubiquitination PhosphoSitePlus
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33203878, 18669648
T335 Phosphorylation PhosphoSitePlus   UniProt 23186163
S337 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S338 Phosphorylation PhosphoSitePlus
T339 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S365 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus   UniProt 23186163
K553 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
T653 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S276 Phosphorylation HPRD 20068231
S333 Phosphorylation HPRD 18669648
S337 Phosphorylation HPRD 18669648
T339 Phosphorylation HPRD 18669648
S548 Phosphorylation HPRD 20068231
S794 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T143 Phosphorylation PhosphoSitePlus
Y606 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T120 P120 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T143 P143 Biomuta DOID:1324 / lung cancer [ cosmic ]
S191 F191 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S254 F254 Biomuta DOID:4159 / skin cancer [ cosmic ]
S333 C333 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S437 L437 Biomuta DOID:1612 / breast cancer [ icgc ]
K628 E628 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]