iPTMnet Report for Q8NEB9 (PIK3C3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NEB9 / PK3C3_HUMAN
Protein Name Phosphatidylinositol 3-kinase catalytic subunit type 3
Gene Name Name: PIK3C3
Synonyms:VPS34;
Organism Homo sapiens (Human)

PRO ID PR:Q8NEB9
DAG View
PRO Name phosphatidylinositol 3-kinase catalytic subunit type 3 (human)
Definition A phosphatidylinositol 3-kinase catalytic subunit type 3 that is encoded in the genome of human.
Short Label hPIK3C3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NEB9 (PIK3C3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K36 Methylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T159 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20513426
T163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   RLIMS-P 28299793
S165 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus   RLIMS-P 24582588
K238 Ubiquitination PhosphoSitePlus
S244 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19664994
S249 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus   UniProt 19369195
S268 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus   UniProt 23186163
K287 Methylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K306 Acetylation IEDB 34357683
Y310 Phosphorylation PhosphoSitePlus   RLIMS-P 24582588
Y321 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S448 Phosphorylation HPRD   PhosphoSitePlus 18691976
S454 Phosphorylation PhosphoSitePlus
S455 Phosphorylation HPRD   PhosphoSitePlus 18691976
K463 Ubiquitination PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K613 Methylation PhosphoSitePlus
T625 Phosphorylation HPRD   PhosphoSitePlus 19413330
K630 Ubiquitination PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T668 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   Signor 20513426
T677 Phosphorylation RLIMS-P 22095288
K706 Ubiquitination PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
K781 Acetylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
Y803 Phosphorylation PhosphoSitePlus
K840 Sumoylation PhosphoSitePlus
K845 Sumoylation PhosphoSitePlus
Y884 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8NEB9 (PIK3C3) T159 Q14457 (BECN1) inhibited_association eFIP 20513426


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:1324 / lung cancer [ cosmic ]
S164 I164 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S168 P168 Biomuta DOID:1324 / lung cancer [ cosmic ]
S244 F244 Biomuta DOID:4159 / skin cancer [ cosmic ]
S276 R276 Biomuta DOID:1612 / breast cancer [ cosmic ]
S282 Y282 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T305 S305 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y310 F310 Biomuta DOID:1319 / brain cancer [ cosmic ]
T324 M324 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K328 T328 Biomuta DOID:363 / uterine cancer [ icgc ]
Y395 C395 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K412 N412 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S455 L455 Biomuta DOID:4159 / skin cancer [ cosmic ]
T625 M625 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]