Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NE63 / HIPK4_HUMAN
Protein Name Homeodomain-interacting protein kinase 4
Gene Name Name: HIPK4
Organism Homo sapiens (Human)

PRO ID PR:Q8NE63
DAG View
PRO Name homeodomain-interacting protein kinase 4 (human)
Definition A homeodomain-interacting protein kinase 4 that is encoded in the genome of human.
Short Label hHIPK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NE63 (HIPK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T122 P122 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S337 C337 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T381 M381 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y392 C392 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]