iPTMnet Report for Q8NDZ2 (SIMC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NDZ2 / SIMC1_HUMAN
Protein Name SUMO-interacting motif-containing protein 1
Gene Name Name: SIMC1
Synonyms:C5orf25,PLEIAD;
Organism Homo sapiens (Human)

PRO ID PR:Q8NDZ2
DAG View
PRO Name SUMO-interacting motif-containing protein 1 (human)
Definition A SUMO-interacting motif-containing protein 1 that is encoded in the genome of human.
Short Label hSIMC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NDZ2 (SIMC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 O-Glycosylation GlyGen 23301498, 30379171
K401 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
T520 Phosphorylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
K550 Acetylation PhosphoSitePlus
T553 Phosphorylation PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
S651 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K657 Ubiquitination PhosphoSitePlus
S791 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
K804 Ubiquitination PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD   PhosphoSitePlus 19651622
S11 Phosphorylation HPRD   PhosphoSitePlus 19651622
S236 Phosphorylation HPRD 17525332
S376 Phosphorylation HPRD 15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S236 F236 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K410 R410 Biomuta DOID:1612 / breast cancer [ icgc ]
S651 F651 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K820 T820 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]