iPTMnet Report for Q8NDX5 (PHC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NDX5 / PHC3_HUMAN
Protein Name Polyhomeotic-like protein 3
Gene Name Name: PHC3
Synonyms:EDR3,PH3;
Organism Homo sapiens (Human)

PRO ID PR:Q8NDX5
DAG View
PRO Name polyhomeotic-like protein 3 (human)
Definition A polyhomeotic-like protein 3 that is encoded in the genome of human.
Short Label hPHC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NDX5 (PHC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S59 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S60 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
K222 Acetylation PhosphoSitePlus
K222 Sumoylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K235 Ubiquitination PhosphoSitePlus
S236 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T237 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S238 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T240 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S242 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T244 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
K256 Ubiquitination PhosphoSitePlus
S263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 17081983, ...20068231
S266 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S279 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T283 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T285 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S318 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
T609 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18669648, 24275569, 19690332, 20068231
T614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18220336
S616 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18669648, 19690332, 20068231
T621 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
T673 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
T674 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S676 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
K691 Sumoylation PhosphoSitePlus
S721 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S723 Phosphorylation PhosphoSitePlus
S724 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K732 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
S744 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 28411811, 30059200, 29485866, 20305658, 29351928, 29237092, 20068230
S761 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S762 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
T764 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
K828 Acetylation PhosphoSitePlus
R837 Methylation PhosphoSitePlus
R839 Methylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
K966 Sumoylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S241 Phosphorylation HPRD 17525332
S275 Phosphorylation HPRD 17081983, 20068231, 19691289
S284 Phosphorylation HPRD 19007248, 20068231, 19691289
S286 Phosphorylation HPRD 19007248
S308 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 20068231
S327 Phosphorylation HPRD 19651622, 18669648, 20068231
S330 Phosphorylation HPRD 17081983, 20068231
T621 Phosphorylation HPRD 18767875, 16565220, 19651622, ...18669648, 18452278, 20068231
T626 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983, 20068231
S628 Phosphorylation HPRD 19651622, 18669648, 16565220, ...20068231, 18452278
T633 Phosphorylation HPRD 17081983
S659 Phosphorylation HPRD 20068231
S661 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 20068231
S735 Phosphorylation HPRD 19691289
S736 Phosphorylation HPRD 18669648
S773 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S774 Phosphorylation HPRD 18669648, 18452278
T776 Phosphorylation HPRD 17081983
S854 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S59 N59 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S228 R228 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:3571 / liver cancer [ icgc ]
T244 A244 Biomuta DOID:3070 / malignant glioma [ icgc, tcga ]
S304 Y304 Biomuta DOID:169 / neuroendocrine tumor [ tcga ]
S304 C304 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T609 I609 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
T621 A621 Biomuta DOID:363 / uterine cancer [ tcga ]
S683 C683 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S683 I683 Biomuta DOID:363 / uterine cancer [ tcga ]
K733 I733 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R839 H839 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R839 C839 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S862 C862 Biomuta DOID:5041 / esophageal cancer [ tcga ]