iPTMnet Report for Q8ND25 (ZNRF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8ND25 / ZNRF1_HUMAN
Protein Name E3 ubiquitin-protein ligase ZNRF1
Gene Name Name: ZNRF1
Synonyms:NIN283;
Organism Homo sapiens (Human)

PRO ID PR:Q8ND25
DAG View
PRO Name E3 ubiquitin-protein ligase ZNRF1 (human)
Definition An E3 ubiquitin-protein ligase ZNRF1 that is encoded in the genome of human.
Short Label hZNRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8ND25 (ZNRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 14561866, 22797923
Y37 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus   UniProt 22797923
S52 Phosphorylation PhosphoSitePlus   UniProt 19690332
S53 Phosphorylation PhosphoSitePlus   UniProt 19690332
Y72 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26572622, 37158982
T106 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus   UniProt 23186163
K144 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
C202 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y37 F37 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y97 C97 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S120 F120 Biomuta DOID:4159 / skin cancer [ cosmic ]
S123 L123 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K150 E150 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
C202 Y202 Biomuta DOID:4159 / skin cancer [ cosmic ]