iPTMnet Report for Q8ND24 (RNF214)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8ND24 / RN214_HUMAN
Protein Name RING finger protein 214
Gene Name Name: RNF214
Organism Homo sapiens (Human)

PRO ID PR:Q8ND24
DAG View
PRO Name RING finger protein 214 (human)
Definition A RING finger protein 214 that is encoded in the genome of human.
Short Label hRNF214
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8ND24 (RNF214) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S15 Phosphorylation PhosphoSitePlus   UniProt 23186163
S25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus   UniProt 23186163
S47 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S51 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
T56 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K136 Methylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus   UniProt 23186163
S200 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
R359 Methylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
R462 Methylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S485 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S497 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S500 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S501 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation PhosphoSitePlus
S511 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S516 Phosphorylation PhosphoSitePlus   UniProt 19690332
S519 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
R619 Methylation PhosphoSitePlus
R621 Methylation PhosphoSitePlus
T633 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
Y644 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 20068231
S47 Phosphorylation HPRD 18767875, 18669648, 20068231
S53 Phosphorylation HPRD 19413330, 18767875
S154 Phosphorylation HPRD 20068231
T399 Phosphorylation HPRD 20068231
S497 Phosphorylation HPRD 18669648
S500 Phosphorylation HPRD 18669648
S501 Phosphorylation HPRD 18669648
S511 Phosphorylation HPRD 18669648, 20068231
S519 Phosphorylation HPRD 20068231
S530 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S47 L47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S47 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T56 S56 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T56 R56 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S134 Y134 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K136 N136 Biomuta DOID:1324 / lung cancer [ cosmic ]
S154 C154 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K161 N161 Biomuta DOID:363 / uterine cancer [ icgc ]
K224 N224 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K277 M277 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R359 W359 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K360 E360 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T399 R399 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R462 Q462 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R462 W462 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S494 F494 Biomuta DOID:1612 / breast cancer [ cosmic ]
S516 P516 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S519 N519 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
R621 W621 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]