iPTMnet Report for Q8ND04 (SMG8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8ND04 / SMG8_HUMAN
Protein Name Nonsense-mediated mRNA decay factor SMG8
Gene Name Name: SMG8
Synonyms:ABC2,C17orf71;
Organism Homo sapiens (Human)

PRO ID PR:Q8ND04
DAG View
PRO Name nonsense-mediated mRNA decay factor SMG8 (human)
Definition A nonsense-mediated mRNA decay factor SMG8 that is encoded in the genome of human.
Short Label hSMG8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8ND04 (SMG8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K64 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus   UniProt 23186163
S132 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
C207 Methylation IEDB 31844290
K236 Ubiquitination PhosphoSitePlus
K242 Methylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K477 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S674 Phosphorylation PhosphoSitePlus
K732 Ubiquitination PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus   UniProt 23186163
T743 Phosphorylation PhosphoSitePlus
Y746 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
R835 Methylation PhosphoSitePlus
K869 Acetylation PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K876 Acetylation PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
Y890 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus   UniProt 23186163
R898 Methylation PhosphoSitePlus   UniProt 24129315
K987 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S469 Phosphorylation HPRD 18669648, 20068231
S667 Phosphorylation HPRD 19651622
S668 Phosphorylation HPRD 19651622
S742 Phosphorylation HPRD 18767875
S753 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C207 Y207 Biomuta DOID:363 / uterine cancer [ icgc ]
K290 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K483 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K589 R589 Biomuta DOID:1324 / lung cancer [ cosmic ]
K589 N589 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S668 F668 Biomuta DOID:4159 / skin cancer [ cosmic ]
S674 L674 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R898 T898 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]