iPTMnet Report for Q8NCM2 (KCNH5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NCM2 / KCNH5_HUMAN
Protein Name Potassium voltage-gated channel subfamily H member 5
Gene Name Name: KCNH5
Synonyms:EAG2;
Organism Homo sapiens (Human)

PRO ID PR:Q8NCM2
DAG View
PRO Name potassium voltage-gated channel subfamily H member 5 (human)
Definition A voltage-gated potassium channel KCNH5 that is encoded in the genome of human.
Short Label hKCNH5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NCM2 (KCNH5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T64 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
S680 O-Glycosylation GlyGen 35254053
K712 Ubiquitination PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus   UniProt 18655026
K804 Acetylation PhosphoSitePlus
K809 Acetylation PhosphoSitePlus
T929 Phosphorylation PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T64 S64 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S142 L142 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
T147 M147 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ]
S161 I161 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K712 M712 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K712 R712 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S756 P756 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K785 T785 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S943 L943 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]