iPTMnet Report for Q8NCE0 (TSEN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NCE0 / SEN2_HUMAN
Protein Name tRNA-splicing endonuclease subunit Sen2
Gene Name Name: TSEN2
Synonyms:SEN2;
Organism Homo sapiens (Human)

PRO ID PR:Q8NCE0
DAG View
PRO Name tRNA-splicing endonuclease subunit Sen2 (human)
Definition A tRNA-splicing endonuclease subunit Sen2 that is encoded in the genome of human.
Short Label hTSEN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NCE0 (TSEN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
Y65 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S240 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y343 Phosphorylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S240 Phosphorylation HPRD 17525332
S408 Phosphorylation HPRD 15345747
S411 Phosphorylation HPRD 15345747
S415 Phosphorylation HPRD 15345747


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y16 S16 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T124 A124 Biomuta DOID:4159 / skin cancer [ cosmic ]
S415 Y415 Biomuta DOID:4159 / skin cancer [ cosmic ]