iPTMnet Report for Q8NC51 (SERBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NC51 / SERB1_HUMAN
Protein Name SERPINE1 mRNA-binding protein 1
Gene Name Name: SERBP1
Synonyms:PAIRBP1;ORFNames:CGI-55;
Organism Homo sapiens (Human)

PRO ID PR:Q8NC51
DAG View
PRO Name plasminogen activator inhibitor 1 RNA-binding protein (human)
Definition A plasminogen activator inhibitor 1 RNA-binding protein that is encoded in the genome of human.
Short Label hSERBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NC51 (SERBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C11 S-Nitrosylation dbSNO 19483679
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 36691768, 18669648, ...24275569, 19690332
K32 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K52 Sumoylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S53 O-Glycosylation GlyGen 31373491
S53 Phosphorylation PhosphoSitePlus
T61 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 30379171, 34725712, 34019948, 21740066, 35132862, 20305658, 31373491
T61 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S63 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
S85 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K92 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Sumoylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K122 Acetylation PhosphoSitePlus   UniProt 19608861
K122 Ubiquitination PhosphoSitePlus
R126 Methylation PhosphoSitePlus
R127 Methylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus   UniProt 19608861
K140 Ubiquitination PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
R163 Methylation PhosphoSitePlus
R165 Methylation PhosphoSitePlus
R175 Methylation PhosphoSitePlus
R177 Methylation PhosphoSitePlus
R181 Methylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
R195 Methylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 36691768
S199 Phosphorylation UniProt 36691768
R201 Methylation PhosphoSitePlus
S202 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
S205 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y207 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus   UniProt 23186163
K211 Acetylation PhosphoSitePlus   UniProt 19608861
K211 Ubiquitination PhosphoSitePlus
R216 Methylation PhosphoSitePlus   UniProt 24129315
S219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163
T226 Phosphorylation UniProt 36691768
K228 Sumoylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
L231 Phosphorylation UniProt 18669648, 17081983
T232 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 36691768, ...18220336, 18669648, 23186163, 19690332, 16964243
K236 Ubiquitination PhosphoSitePlus
Y237 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
K240 Phosphorylation UniProt 18669648
K240 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S252 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T255 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T258 Phosphorylation PhosphoSitePlus
K281 Sumoylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K327 Methylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S328 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...24275569
S338 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K346 Ubiquitination PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
R364 Methylation PhosphoSitePlus   UniProt 24129315
R367 Methylation PhosphoSitePlus   UniProt 24129315
R370 Methylation PhosphoSitePlus   UniProt 24129315
R373 Methylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S394 O-Glycosylation GlyGen 31373491
S394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20058876, 19664994, 18452278, ...19651622, 18669648, 15345747, 19415658
S53 Phosphorylation HPRD 20068230
T61 Phosphorylation HPRD 17287340
S85 Phosphorylation HPRD 17287340
S197 Phosphorylation HPRD 17287340, 17081983
S199 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD 18767875
S203 Phosphorylation HPRD 18767875, 17287340
S219 Phosphorylation HPRD 17081983
S221 Phosphorylation HPRD 18669648, 17287340, 17081983
T232 Phosphorylation HPRD 20166139, 17924679, 19007248, ...18452278
S234 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 18452278, 19651622, 18669648, 20166139, 17924679
Y237 Phosphorylation HPRD 18669648
S247 Phosphorylation HPRD 17081983
S252 Phosphorylation HPRD 19007248
S328 Phosphorylation HPRD 17924679, 17287340, 18452278
S330 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18669648, 17924679
S338 Phosphorylation HPRD 18669648, 18452278
T388 Phosphorylation HPRD 17081983
S391 Phosphorylation HPRD 18669648, 15345747, 18452278
S392 Phosphorylation HPRD 18669648, 17081983, 18452278
S394 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20058876, 19664994, 18452278, ...19651622, 18669648, 15345747, 19415658
S53 Phosphorylation HPRD 20068230
T61 Phosphorylation HPRD 17287340
S85 Phosphorylation HPRD 17287340
S197 Phosphorylation HPRD   PhosphoSitePlus 17287340, 17081983
S199 Phosphorylation HPRD 17081983
R201 Methylation PhosphoSitePlus
S213 Phosphorylation HPRD 17081983
S215 Phosphorylation HPRD 18669648, 17287340, 17081983
T226 Phosphorylation HPRD 20166139, 17924679, 19007248, ...18452278
S228 Phosphorylation HPRD 19413330, 17322306, 17287340, ...16964243, 18452278, 19651622, 18669648, 20166139, 17924679
Y231 Phosphorylation HPRD 18669648
S241 Phosphorylation HPRD 17081983
S246 Phosphorylation HPRD 19007248
S322 Phosphorylation HPRD 17924679, 17287340, 18452278
S324 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18669648, 17924679
S332 Phosphorylation HPRD 18669648, 18452278
T382 Phosphorylation HPRD 17081983
S385 Phosphorylation HPRD 18669648, 15345747, 18452278
S386 Phosphorylation HPRD 18669648, 17081983, 18452278
S388 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD   phospho.ELM 20058876, 19664994, 18452278, ...19651622, 18669648, 15345747, 19415658
S53 Phosphorylation HPRD 20068230
T61 Phosphorylation HPRD 17287340
S85 Phosphorylation HPRD 17287340
S197 Phosphorylation HPRD 17287340, 17081983
S199 Phosphorylation HPRD 17081983
S202 Phosphorylation HPRD   phospho.ELM 18767875, 18220336
S203 Phosphorylation HPRD 18767875, 17287340
Y207 Phosphorylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus
S219 Phosphorylation HPRD   PhosphoSitePlus 17081983
S221 Phosphorylation HPRD   phospho.ELM 18669648, 17287340, 17081983
K228 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S237 Phosphorylation HPRD   PhosphoSitePlus 17081983, 19007248, 18452278, ...19651622, 18669648
T240 Phosphorylation HPRD   PhosphoSitePlus 18669648
T243 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S313 Phosphorylation HPRD 17924679, 17287340, 18452278
S315 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18669648, 17924679
S323 Phosphorylation HPRD 18669648, 18452278
T373 Phosphorylation HPRD 17081983
S376 Phosphorylation HPRD 18669648, 15345747, 18452278
S377 Phosphorylation HPRD 18669648, 17081983, 18452278
S379 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 20058876, 19664994, 18452278, ...19651622, 18669648, 15345747, 19415658
S53 Phosphorylation HPRD 20068230
T61 Phosphorylation HPRD 17287340
S85 Phosphorylation HPRD 17287340
S197 Phosphorylation HPRD 17287340, 17081983
S199 Phosphorylation HPRD 17081983
S213 Phosphorylation HPRD 17081983
S215 Phosphorylation HPRD 17287340, 17081983
S231 Phosphorylation HPRD 19651622, 18669648, 18452278, ...19007248, 17081983
T234 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 17924679, 17287340, 18452278
S309 Phosphorylation HPRD 17322306, 17287340, 18767875, ...19651622, 18669648, 17924679
S317 Phosphorylation HPRD 18669648, 18452278
T367 Phosphorylation HPRD 17081983
S370 Phosphorylation HPRD 18669648, 15345747, 18452278
S371 Phosphorylation HPRD 18669648, 17081983, 18452278
S373 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K52 M52 Biomuta DOID:4159 / skin cancer [ cosmic ]
K122 N122 Biomuta DOID:363 / uterine cancer [ icgc ]
R160 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
R163 Q163 Biomuta DOID:363 / uterine cancer [ icgc ]
R165 H165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R175 H175 Biomuta DOID:363 / uterine cancer [ icgc ]
R175 C175 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R177 H177 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R188 C188 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S202 F202 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R216 H216 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S228 P228 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K228 N228 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S231 L231 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S234 P234 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T234 I234 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K236 N236 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S237 L237 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T240 I240 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y246 D246 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S246 L246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S252 L252 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T255 I255 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S317 P317 Biomuta [ cosmic ]
K320 R320 Biomuta DOID:1319 / brain cancer [ cosmic ]
S323 P323 Biomuta [ cosmic ]
S332 P332 Biomuta [ cosmic ]
S338 P338 Biomuta [ cosmic ]
S353 F353 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R367 C367 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
S371 N371 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R373 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S377 N377 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S386 N386 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic ]
S392 N392 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]