Protein Information

Cytoscape View

UniProt AC / UniProt ID Q8NBS9 / TXND5_HUMAN
Protein Name Thioredoxin domain-containing protein 5 precursor
Gene Name Name: TXNDC5
Organism Homo sapiens (Human)

DAG View
PRO Name thioredoxin domain-containing protein 5 (human)
Definition A thioredoxin domain-containing protein 5 that is encoded in the genome of human.
Short Label hTXNDC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q8NBS9 (TXNDC5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T72 O-Glycosylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
R134 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T174 O-Glycosylation GlyGen 30459171
K221 Methylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
T304 O-Glycosylation GlyGen 30459171
T306 O-Glycosylation GlyGen 30459171
S308 O-Glycosylation GlyGen 30459171
K344 Ubiquitination PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
N386 N-Glycosylation GlyGen 24190977
K390 Acetylation PhosphoSitePlus
K407 Acetylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y115 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T72 K72 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T122 M122 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K241 N241 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
K244 T244 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y289 * Biomuta DOID:3571 / liver cancer [ icgc ]
S292 L292 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T306 M306 Biomuta DOID:1612 / breast cancer [ cosmic ]