iPTMnet Report for Q8NBP7 (PCSK9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NBP7 / PCSK9_HUMAN
Protein Name Proprotein convertase subtilisin/kexin type 9 precursor
Gene Name Name: PCSK9
Synonyms:NARC1;ORFNames:PSEC0052;
Organism Homo sapiens (Human)

PRO ID PR:Q8NBP7
DAG View
PRO Name proprotein convertase subtilisin/kexin type 9 (human)
Definition A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human.
Short Label hPCSK9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NBP7 (PCSK9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18498363, 26091039, 31949048
K69 Ubiquitination PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S235 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K243 Ubiquitination PhosphoSitePlus
N533 N-Glycosylation GlyGen   UniProt 23090970, 16912035, 24190977
S688 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 29699916, 23186163, ...17081983, 18498363, 18669648, 26091039, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 17081983
S235 Phosphorylation HPRD 18669648
S688 Phosphorylation HPRD 18702456, 18669648, 19664994, ...17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 L91 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S91 I91 Biomuta DOID:263 / kidney cancer [ cosmic ]
S91 T91 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]