iPTMnet Report for Q8NBF2 (NHLRC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NBF2 / NHLC2_HUMAN
Protein Name NHL repeat-containing protein 2
Gene Name Name: NHLRC2
Organism Homo sapiens (Human)

PRO ID PR:Q8NBF2
DAG View
PRO Name NHL repeat-containing protein 2 (human)
Definition An NHL repeat-containing protein 2 that is encoded in the genome of human.
Short Label hNHLRC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NBF2 (NHLRC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
R237 Methylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 20068231
Y403 Phosphorylation HPRD 18083107
T590 Phosphorylation HPRD 17924679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R7 L7 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S12 C12 Biomuta DOID:4159 / skin cancer [ cosmic ]
S12 F12 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y190 C190 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K208 R208 Biomuta DOID:1324 / lung cancer [ cosmic ]
K208 T208 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K208 N208 Biomuta DOID:363 / uterine cancer [ icgc ]
S567 F567 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S567 Y567 Biomuta DOID:363 / uterine cancer [ icgc ]
T590 I590 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]