iPTMnet Report for Q8NBE8 (KLHL23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NBE8 / KLH23_HUMAN
Protein Name Kelch-like protein 23
Gene Name Name: KLHL23
Organism Homo sapiens (Human)

PRO ID PR:Q8NBE8
DAG View
PRO Name kelch-like protein 23 (human)
Definition A kelch-like protein 23 that is encoded in the genome of human.
Short Label hKLHL23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NBE8 (KLHL23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
C151 Methylation IEDB 31844290
S164 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
C363 Methylation IEDB 31844290
K379 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
C425 Methylation IEDB 31844290
C431 Methylation IEDB 31844290
C460 Methylation IEDB 31844290
R489 Methylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S244 R244 Biomuta DOID:4159 / skin cancer [ cosmic ]
S244 T244 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K251 N251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y257 H257 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C425 R425 Biomuta DOID:9256 / colorectal cancer [ cosmic ]