iPTMnet Report for Q8N9I0 (SYT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N9I0 / SYT2_HUMAN
Protein Name Synaptotagmin-2
Gene Name Name: SYT2
Organism Homo sapiens (Human)

PRO ID PR:Q8N9I0
DAG View
PRO Name synaptotagmin-2 (human)
Definition A synaptotagmin-2 that is encoded in the genome of human.
Short Label hSYT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N9I0 (SYT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Acetylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
T199 Phosphorylation neXtProt   Signor 15350218
T199 Phosphorylation Q9H4A3 (WNK1) neXtProt   Signor 15350218
K299 Acetylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
T383 Phosphorylation neXtProt   PhosphoSitePlus 15350218
T383 Phosphorylation Q9H4A3 (WNK1) neXtProt 15350218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 R48 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T122 I122 Biomuta DOID:1324 / lung cancer [ cosmic ]
T125 I125 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y309 C309 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S378 I378 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S378 N378 Biomuta DOID:363 / uterine cancer [ icgc ]
T383 I383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]