Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N884 / CGAS_HUMAN
Protein Name Cyclic GMP-AMP synthase
Gene Name Name: CGAS
Synonyms:C6orf150;
Organism Homo sapiens (Human)

PRO ID PR:Q8N884
DAG View
PRO Name cyclic GMP-AMP synthase (human)
Definition A protein MB21D1 that is encoded in the genome of human.
Short Label hCGAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N884 (CGAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus   UniProt 19608861, 30799039
K7 Methylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus   UniProt 30799039
S64 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K82 Methylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 20068231
K164 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus   UniProt 30356214
K231 Sumoylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K285 Sumoylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
K301 Methylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K362 Methylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus   UniProt 30799039
K384 Sumoylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K392 Acetylation PhosphoSitePlus   UniProt 30799039
K392 Ubiquitination PhosphoSitePlus
K394 Acetylation PhosphoSitePlus   UniProt 30799039
K394 Sumoylation PhosphoSitePlus
K414 Acetylation PhosphoSitePlus   UniProt 19608861, 30799039
K414 Ubiquitination PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K479 Sumoylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 20068231
Y248 Phosphorylation HPRD 15592455
T294 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S116 Y116 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T181 M181 Biomuta DOID:1115 / sarcoma [ tcga ]
Y248 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K432 T432 Biomuta DOID:363 / uterine cancer [ tcga ]
K479 T479 Biomuta DOID:363 / uterine cancer [ tcga ]