iPTMnet Report for Q8N7H5 (PAF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N7H5 / PAF1_HUMAN
Protein Name RNA polymerase II-associated factor 1 homolog
Gene Name Name: PAF1
Synonyms:PD2;
Organism Homo sapiens (Human)

PRO ID PR:Q8N7H5
DAG View
PRO Name RNA polymerase II-associated factor 1 homolog (human)
Definition An RNA polymerase II-associated factor 1 that is encoded in the genome of human.
Short Label hPAF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N7H5 (PAF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S38 O-Glycosylation GlyGen 34019948, 28510447, 33465208
S38 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus   UniProt 23186163
K119 Acetylation PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K133 Sumoylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
K150 Sumoylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K154 Sumoylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
T182 O-Glycosylation GlyGen 33465208
K188 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S195 O-Glycosylation GlyGen 34019948, 28510447, 33465208
S195 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S117 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 20068231
T232 Phosphorylation HPRD 20068231
S456 Phosphorylation HPRD 18669648, 17081983, 18452278
S460 Phosphorylation HPRD 18669648, 17081983, 18452278
S466 Phosphorylation HPRD 18669648, 17081983, 18452278
S484 Phosphorylation HPRD 18452278
S486 Phosphorylation HPRD 18452278
S505 Phosphorylation HPRD 18452278
S510 Phosphorylation HPRD 18452278
S521 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 I38 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K71 R71 Biomuta DOID:263 / kidney cancer [ cosmic ]
S117 R117 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K133 N133 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y136 C136 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S147 F147 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K359 T359 Biomuta DOID:3571 / liver cancer [ cosmic ]
S394 L394 Biomuta DOID:363 / uterine cancer [ cosmic ]
S414 L414 Biomuta DOID:4159 / skin cancer [ cosmic ]
S460 Y460 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S493 G493 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S510 L510 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]